ACT001 attenuates microglia-mediated neuroinflammation after traumatic brain injury via inhibiting AKT/NFκB/NLRP3 pathway

BACKGROUND: Microglia-mediated neuroinflammatory response following traumatic brain injury (TBI) is considered as a vital secondary injury factor, which drives trauma-induced neurodegeneration and is lack of efficient treatment. ACT001, a sesquiterpene lactone derivative, is reportedly involved in a...

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Detalles Bibliográficos
Autores principales: Cai, Lin, Gong, Qiuyuan, Qi, Lin, Xu, Tongtong, Suo, Qian, Li, Xiang, Wang, Wei, Jing, Yao, Yang, Dianxu, Xu, Zhiming, Yuan, Fang, Tang, Yaohui, Yang, Guoyuan, Ding, Jun, Chen, Hao, Tian, Hengli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035258/
https://www.ncbi.nlm.nih.gov/pubmed/35461293
http://dx.doi.org/10.1186/s12964-022-00862-y

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