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A case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium

BACKGROUND: Gastrointestinal stromal tumors (GISTs), which are the most common soft tissue tumors of the gastrointestinal tract, originate from Cajal interneurons. The main metastatic sites of GISTs are the liver and intra-abdominal cavity, and metastasis to the heart is rare. CASE PRESENTATION: The...

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Autores principales: Takasaki, Tadashi, Tsuji, Takashi, Nakayama, Shogo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035378/
https://www.ncbi.nlm.nih.gov/pubmed/35467179
http://dx.doi.org/10.1186/s40792-022-01433-6
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author Takasaki, Tadashi
Tsuji, Takashi
Nakayama, Shogo
author_facet Takasaki, Tadashi
Tsuji, Takashi
Nakayama, Shogo
author_sort Takasaki, Tadashi
collection PubMed
description BACKGROUND: Gastrointestinal stromal tumors (GISTs), which are the most common soft tissue tumors of the gastrointestinal tract, originate from Cajal interneurons. The main metastatic sites of GISTs are the liver and intra-abdominal cavity, and metastasis to the heart is rare. CASE PRESENTATION: The patient was a 78-year-old man who was diagnosed with a rectal GIST 20 years previously. Since then, he had undergone repeated operations for metastasis. A follow-up thoracoabdominal computed tomography scan 4 months prior to the operation revealed GIST metastasis to the left ventricular myocardium. The patient wanted the tumor removed and consequently underwent an operation. The surgical findings showed a 3-cm × 3-cm mass in the lateral wall of the left ventricle. The mass was resected from the left ventricular wall in the shape of a tear drop. The left ventricular cavity was closed with a 4–0 polypropylene mattress suture and continuous suture. Postoperative histopathological findings showed nodular tumor growth consisting of bundles of spindle-shaped cells in the myocardium. The margins were negative. Immunostaining showed c-KIT (CD17) positivity and CD34 positivity, consistent with GIST metastasis. CONCLUSIONS: This case involved GIST metastasis to the heart muscle, which has rarely been reported worldwide.
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spelling pubmed-90353782022-04-25 A case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium Takasaki, Tadashi Tsuji, Takashi Nakayama, Shogo Surg Case Rep Case Report BACKGROUND: Gastrointestinal stromal tumors (GISTs), which are the most common soft tissue tumors of the gastrointestinal tract, originate from Cajal interneurons. The main metastatic sites of GISTs are the liver and intra-abdominal cavity, and metastasis to the heart is rare. CASE PRESENTATION: The patient was a 78-year-old man who was diagnosed with a rectal GIST 20 years previously. Since then, he had undergone repeated operations for metastasis. A follow-up thoracoabdominal computed tomography scan 4 months prior to the operation revealed GIST metastasis to the left ventricular myocardium. The patient wanted the tumor removed and consequently underwent an operation. The surgical findings showed a 3-cm × 3-cm mass in the lateral wall of the left ventricle. The mass was resected from the left ventricular wall in the shape of a tear drop. The left ventricular cavity was closed with a 4–0 polypropylene mattress suture and continuous suture. Postoperative histopathological findings showed nodular tumor growth consisting of bundles of spindle-shaped cells in the myocardium. The margins were negative. Immunostaining showed c-KIT (CD17) positivity and CD34 positivity, consistent with GIST metastasis. CONCLUSIONS: This case involved GIST metastasis to the heart muscle, which has rarely been reported worldwide. Springer Berlin Heidelberg 2022-04-25 /pmc/articles/PMC9035378/ /pubmed/35467179 http://dx.doi.org/10.1186/s40792-022-01433-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Takasaki, Tadashi
Tsuji, Takashi
Nakayama, Shogo
A case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium
title A case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium
title_full A case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium
title_fullStr A case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium
title_full_unstemmed A case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium
title_short A case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium
title_sort case of gastrointestinal stromal tumor metastasized to the left ventricular myocardium
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035378/
https://www.ncbi.nlm.nih.gov/pubmed/35467179
http://dx.doi.org/10.1186/s40792-022-01433-6
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