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The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population

PURPOSE: This study investigates the relationship between baseline plasma Aβ and cognitive decline during follow-up in cognitively unimpaired population. MATERIALS AND METHODS: Cognitively unimpaired population was selected from people who lived in the suburbs of Xi’an, China. The levels of plasma A...

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Autores principales: Wang, Jin, Gao, Ling, Liu, Jie, Dang, Liangjun, Wei, Shan, Hu, Ningwei, Gao, Yao, Peng, Wei, Shang, Suhang, Huo, Kang, Wang, Jingyi, Qu, Qiumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035463/
https://www.ncbi.nlm.nih.gov/pubmed/35480964
http://dx.doi.org/10.2147/CIA.S357994
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author Wang, Jin
Gao, Ling
Liu, Jie
Dang, Liangjun
Wei, Shan
Hu, Ningwei
Gao, Yao
Peng, Wei
Shang, Suhang
Huo, Kang
Wang, Jingyi
Qu, Qiumin
author_facet Wang, Jin
Gao, Ling
Liu, Jie
Dang, Liangjun
Wei, Shan
Hu, Ningwei
Gao, Yao
Peng, Wei
Shang, Suhang
Huo, Kang
Wang, Jingyi
Qu, Qiumin
author_sort Wang, Jin
collection PubMed
description PURPOSE: This study investigates the relationship between baseline plasma Aβ and cognitive decline during follow-up in cognitively unimpaired population. MATERIALS AND METHODS: Cognitively unimpaired population was selected from people who lived in the suburbs of Xi’an, China. The levels of plasma Aβ(1-42) and Aβ(1-40) were tested using commercial enzyme-linked immunosorbent assay (ELISA). The mini-mental state examination (MMSE) and neuropsychological battery were used to assess cognition. Two years later, MMSE was tested again, and significant cognitive decline was defined as a decrease in MMSE scores ≥5 points. Logistic regression analysis was performed to analyze the relationship between baseline plasma Aβ and cognitive change during the two-year follow-up. RESULTS: A total of 1144 participants completed the study, among whom 59 subjects (5.2%) presented significant cognitive decline. The high plasma Aβ(1-42) level group had more significant cognitive decline (P = 0.023). Multivariable logistic regression analysis showed that significant cognitive decline was associated with the high levels of baseline plasma Aβ(1-42) (OR = 1.043, 95% CI: 1.005–1.083, P = 0.026). However, significant cognitive decline was not associated with baseline plasma Aβ(1-40) levels and Aβ(1-42) /Aβ(1-40) ratio. CONCLUSION: Population with high level of baseline plasma Aβ(1-42) manifested significant cognitive decline over 2 years; however, further investigation on the dynamics of plasma Aβ and long-term follow-up are needed.
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spelling pubmed-90354632022-04-26 The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population Wang, Jin Gao, Ling Liu, Jie Dang, Liangjun Wei, Shan Hu, Ningwei Gao, Yao Peng, Wei Shang, Suhang Huo, Kang Wang, Jingyi Qu, Qiumin Clin Interv Aging Original Research PURPOSE: This study investigates the relationship between baseline plasma Aβ and cognitive decline during follow-up in cognitively unimpaired population. MATERIALS AND METHODS: Cognitively unimpaired population was selected from people who lived in the suburbs of Xi’an, China. The levels of plasma Aβ(1-42) and Aβ(1-40) were tested using commercial enzyme-linked immunosorbent assay (ELISA). The mini-mental state examination (MMSE) and neuropsychological battery were used to assess cognition. Two years later, MMSE was tested again, and significant cognitive decline was defined as a decrease in MMSE scores ≥5 points. Logistic regression analysis was performed to analyze the relationship between baseline plasma Aβ and cognitive change during the two-year follow-up. RESULTS: A total of 1144 participants completed the study, among whom 59 subjects (5.2%) presented significant cognitive decline. The high plasma Aβ(1-42) level group had more significant cognitive decline (P = 0.023). Multivariable logistic regression analysis showed that significant cognitive decline was associated with the high levels of baseline plasma Aβ(1-42) (OR = 1.043, 95% CI: 1.005–1.083, P = 0.026). However, significant cognitive decline was not associated with baseline plasma Aβ(1-40) levels and Aβ(1-42) /Aβ(1-40) ratio. CONCLUSION: Population with high level of baseline plasma Aβ(1-42) manifested significant cognitive decline over 2 years; however, further investigation on the dynamics of plasma Aβ and long-term follow-up are needed. Dove 2022-04-20 /pmc/articles/PMC9035463/ /pubmed/35480964 http://dx.doi.org/10.2147/CIA.S357994 Text en © 2022 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wang, Jin
Gao, Ling
Liu, Jie
Dang, Liangjun
Wei, Shan
Hu, Ningwei
Gao, Yao
Peng, Wei
Shang, Suhang
Huo, Kang
Wang, Jingyi
Qu, Qiumin
The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population
title The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population
title_full The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population
title_fullStr The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population
title_full_unstemmed The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population
title_short The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population
title_sort association of plasma amyloid-β and cognitive decline in cognitively unimpaired population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035463/
https://www.ncbi.nlm.nih.gov/pubmed/35480964
http://dx.doi.org/10.2147/CIA.S357994
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