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miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1

Gastric cancer is a kind of gastrointestinal tumor with high morbidity and mortality. Finding effective methods for early diagnosis and treatment of gastric cancer has important significance and application prospects. MicroRNAs without protein coding potential affect the occurrence and development o...

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Autores principales: Yan, Jiexin, Dai, Lu, Yuan, Jun, Pang, Min, Wang, Yueqiu, Lin, Lang, Shi, Yawei, Wu, Fuli, Nie, Rongping, Chen, Qiuling, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035523/
https://www.ncbi.nlm.nih.gov/pubmed/35480301
http://dx.doi.org/10.3389/fgene.2022.855355
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author Yan, Jiexin
Dai, Lu
Yuan, Jun
Pang, Min
Wang, Yueqiu
Lin, Lang
Shi, Yawei
Wu, Fuli
Nie, Rongping
Chen, Qiuling
Wang, Lei
author_facet Yan, Jiexin
Dai, Lu
Yuan, Jun
Pang, Min
Wang, Yueqiu
Lin, Lang
Shi, Yawei
Wu, Fuli
Nie, Rongping
Chen, Qiuling
Wang, Lei
author_sort Yan, Jiexin
collection PubMed
description Gastric cancer is a kind of gastrointestinal tumor with high morbidity and mortality. Finding effective methods for early diagnosis and treatment of gastric cancer has important significance and application prospects. MicroRNAs without protein coding potential affect the occurrence and development of gastric cancer. This study aims to explore the biological function and mechanism of microRNA-107 (miR-107) in gastric cancer. The results show that miR-107 is low expressed in gastric cancer, while TRIAP1 is highly expressed; the overexpression of miR-107 can inhibit the progression of gastric cancer in vivo and in vitro, while the overexpression plasmid of TRIAP1 can restore the miR-107 mimic-induced cell proliferation and metastasis inhibition, and the small interfering RNA of TRIAP1 can inhibit the cell proliferation and invasion induced by miR-107 inhibitor. In conclusion, the results of this study show that miR-107 can inhibit the proliferation of gastric cancer in vivo and in vitro by targeting TRIAP1.
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spelling pubmed-90355232022-04-26 miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1 Yan, Jiexin Dai, Lu Yuan, Jun Pang, Min Wang, Yueqiu Lin, Lang Shi, Yawei Wu, Fuli Nie, Rongping Chen, Qiuling Wang, Lei Front Genet Genetics Gastric cancer is a kind of gastrointestinal tumor with high morbidity and mortality. Finding effective methods for early diagnosis and treatment of gastric cancer has important significance and application prospects. MicroRNAs without protein coding potential affect the occurrence and development of gastric cancer. This study aims to explore the biological function and mechanism of microRNA-107 (miR-107) in gastric cancer. The results show that miR-107 is low expressed in gastric cancer, while TRIAP1 is highly expressed; the overexpression of miR-107 can inhibit the progression of gastric cancer in vivo and in vitro, while the overexpression plasmid of TRIAP1 can restore the miR-107 mimic-induced cell proliferation and metastasis inhibition, and the small interfering RNA of TRIAP1 can inhibit the cell proliferation and invasion induced by miR-107 inhibitor. In conclusion, the results of this study show that miR-107 can inhibit the proliferation of gastric cancer in vivo and in vitro by targeting TRIAP1. Frontiers Media S.A. 2022-04-11 /pmc/articles/PMC9035523/ /pubmed/35480301 http://dx.doi.org/10.3389/fgene.2022.855355 Text en Copyright © 2022 Yan, Dai, Yuan, Pang, Wang, Lin, Shi, Wu, Nie, Chen and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Yan, Jiexin
Dai, Lu
Yuan, Jun
Pang, Min
Wang, Yueqiu
Lin, Lang
Shi, Yawei
Wu, Fuli
Nie, Rongping
Chen, Qiuling
Wang, Lei
miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1
title miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1
title_full miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1
title_fullStr miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1
title_full_unstemmed miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1
title_short miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1
title_sort mir-107 inhibits the proliferation of gastric cancer cells in vivo and in vitro by targeting triap1
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035523/
https://www.ncbi.nlm.nih.gov/pubmed/35480301
http://dx.doi.org/10.3389/fgene.2022.855355
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