MutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells

Autoimmune hepatitis (AIH) is an inflammatory liver disease driven by the hyperactivation of various intrahepatic antigen‐specific T cells due to a breach of immune tolerance. Studies in immunometabolism demonstrate that activated T cells harbor increased levels of reactive oxygen species that cause...

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Detalles Bibliográficos
Autores principales: Chen, Yong, Hua, Xiangwei, Huang, Bingyuan, Karsten, Stella, You, Zhengrui, Li, Bo, Li, You, Li, Yikang, Liang, Jubo, Zhang, Jun, Wei, Yiran, Chen, Ruiling, Lyu, Zhuwan, Xiao, Xiao, Lian, Min, Wei, Jue, Fang, Jingyuan, Miao, Qi, Wang, Qixia, Berglung, Ulrika Warpman, Tang, Ruqi, Helleday, Thomas, Ma, Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035570/
https://www.ncbi.nlm.nih.gov/pubmed/34894107
http://dx.doi.org/10.1002/hep4.1862

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