Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes

C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions...

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Autores principales: Cai, Kunliang, Ran, Yuzhao, Sun, Wenbo, Gao, Sen, Li, Jin, Wan, Jinqiao, Liu, Guansai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035600/
https://www.ncbi.nlm.nih.gov/pubmed/35480389
http://dx.doi.org/10.3389/fchem.2022.851674
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author Cai, Kunliang
Ran, Yuzhao
Sun, Wenbo
Gao, Sen
Li, Jin
Wan, Jinqiao
Liu, Guansai
author_facet Cai, Kunliang
Ran, Yuzhao
Sun, Wenbo
Gao, Sen
Li, Jin
Wan, Jinqiao
Liu, Guansai
author_sort Cai, Kunliang
collection PubMed
description C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp(3))–N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis.
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spelling pubmed-90356002022-04-26 Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes Cai, Kunliang Ran, Yuzhao Sun, Wenbo Gao, Sen Li, Jin Wan, Jinqiao Liu, Guansai Front Chem Chemistry C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp(3))–N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis. Frontiers Media S.A. 2022-04-11 /pmc/articles/PMC9035600/ /pubmed/35480389 http://dx.doi.org/10.3389/fchem.2022.851674 Text en Copyright © 2022 Cai, Ran, Sun, Gao, Li, Wan and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Cai, Kunliang
Ran, Yuzhao
Sun, Wenbo
Gao, Sen
Li, Jin
Wan, Jinqiao
Liu, Guansai
Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
title Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
title_full Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
title_fullStr Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
title_full_unstemmed Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
title_short Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
title_sort palladium-mediated hydroamination of dna-conjugated aryl alkenes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035600/
https://www.ncbi.nlm.nih.gov/pubmed/35480389
http://dx.doi.org/10.3389/fchem.2022.851674
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