RAB18 is a key regulator of GalNAc-conjugated siRNA-induced silencing in Hep3B cells

Small interfering RNA (siRNA) therapeutics have developed rapidly in recent years, despite the challenges associated with delivery of large, highly charged nucleic acids. Delivery of siRNA therapeutics to the liver has been established, with conjugation of siRNA to N-acetylgalactosamine (GalNAc) pro...

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Detalles Bibliográficos
Autores principales: Lu, Jiamiao, Swearingen, Elissa, Hardy, Miki, Collins, Patrick, Wu, Bin, Yuan, Eric, Lu, Daniel, Li, Chi-Ming, Wang, Songli, Ollmann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035644/
https://www.ncbi.nlm.nih.gov/pubmed/35505960
http://dx.doi.org/10.1016/j.omtn.2022.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035644/
https://www.ncbi.nlm.nih.gov/pubmed/35505960
http://dx.doi.org/10.1016/j.omtn.2022.04.003

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