From the PnTx2-6 Toxin to the PnPP-19 Engineered Peptide: Therapeutic Potential in Erectile Dysfunction, Nociception, and Glaucoma

The venom of the “armed” spider Phoneutria nigriventer comprises several potent toxins. One of the most toxic components from this venom is the neurotoxin PnTx2-6 (LD(50) = ∼ 0.7 μg/mouse, 48 residues, five disulfide bridges, MW = 5,289.31 Da), which slows down the inactivation of various Na(+) chan...

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Detalles Bibliográficos
Autores principales: da Silva, Carolina Nunes, Nunes, Kenia Pedrosa, Dourado, Lays Fernanda Nunes, Vieira, Thayllon Oliveira, Mariano, Xavier Maia, Cunha Junior, Armando da Silva, de Lima, Maria Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035689/
https://www.ncbi.nlm.nih.gov/pubmed/35480885
http://dx.doi.org/10.3389/fmolb.2022.831823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035689/
https://www.ncbi.nlm.nih.gov/pubmed/35480885
http://dx.doi.org/10.3389/fmolb.2022.831823

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