Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel

Calcium homeostasis modulator 1 (CALHM1) is a voltage- and Ca(2+)-gated ATP channel that plays an important role in neuronal signaling. However, as the previously reported CALHM structures are all in the ATP-conducting state, the gating mechanism of ATP permeation is still elusive. Here, we report c...

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Detalles Bibliográficos
Autores principales: Ren, Yue, Li, Yang, Wang, Yaojie, Wen, Tianlei, Lu, Xuhang, Chang, Shenghai, Zhang, Xing, Shen, Yuequan, Yang, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035704/
https://www.ncbi.nlm.nih.gov/pubmed/35339491
http://dx.doi.org/10.1016/j.jbc.2022.101838

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