Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling

There is growing evidence that mammalian cells deploy a mitochondria-associated metabolon called the purinosome to perform channeled de novo purine biosynthesis (DNPB). However, the molecular mechanisms of this substrate-channeling pathway are not well defined. Here, we present molecular evidence of...

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Detalles Bibliográficos
Autores principales: He, Jingxuan, Zou, Ling-Nan, Pareek, Vidhi, Benkovic, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035706/
https://www.ncbi.nlm.nih.gov/pubmed/35331738
http://dx.doi.org/10.1016/j.jbc.2022.101853

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