Capsaicin inhibits intestinal Cl(-) secretion and promotes Na(+) absorption by blocking TRPV4 channels in healthy and colitic mice

Although capsaicin has been studied extensively as an activator of the transient receptor potential vanilloid cation channel subtype 1 (TRPV1) channels in sensory neurons, little is known about its TRPV1-independent actions in gastrointestinal health and disease. Here, we aimed to investigate the ph...

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Detalles Bibliográficos
Autores principales: Wan, Hanxing, Chen, Xiong Ying, Zhang, Fenglian, Chen, Jun, Chu, Fenglan, Sellers, Zachary M., Xu, Feng, Dong, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035713/
https://www.ncbi.nlm.nih.gov/pubmed/35314195
http://dx.doi.org/10.1016/j.jbc.2022.101847

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