Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-κB through a targetable second interaction with upstream activator IKK2

Canonical NF-κB signaling through the inhibitor of κB kinase (IKK) complex requires induction of IKK2/IKKβ subunit catalytic activity via specific phosphorylation within its activation loop. This process is known to be dependent upon the accessory ubiquitin (Ub)-binding subunit NF-κB essential modul...

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Detalles Bibliográficos
Autores principales: Ko, Myung Soo, Cohen, Samantha N., Polley, Smarajit, Mahata, Sushil K., Biswas, Tapan, Huxford, Tom, Ghosh, Gourisankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035715/
https://www.ncbi.nlm.nih.gov/pubmed/35339487
http://dx.doi.org/10.1016/j.jbc.2022.101864

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