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Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy
The observation that a pathophysiological link might exist between Alzheimer's disease (AD) and epilepsy dates back to the identification of the first cases of the pathology itself and is now strongly supported by an ever-increasing mountain of literature. An overwhelming majority of data sugge...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035794/ https://www.ncbi.nlm.nih.gov/pubmed/35481265 http://dx.doi.org/10.3389/fneur.2022.836292 |
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author | B. Szabo, Anna Cretin, Benjamin Gérard, Fleur Curot, Jonathan J. Barbeau, Emmanuel Pariente, Jérémie Dahan, Lionel Valton, Luc |
author_facet | B. Szabo, Anna Cretin, Benjamin Gérard, Fleur Curot, Jonathan J. Barbeau, Emmanuel Pariente, Jérémie Dahan, Lionel Valton, Luc |
author_sort | B. Szabo, Anna |
collection | PubMed |
description | The observation that a pathophysiological link might exist between Alzheimer's disease (AD) and epilepsy dates back to the identification of the first cases of the pathology itself and is now strongly supported by an ever-increasing mountain of literature. An overwhelming majority of data suggests not only a higher prevalence of epilepsy in Alzheimer's disease compared to healthy aging, but also that AD patients with a comorbid epileptic syndrome, even subclinical, have a steeper cognitive decline. Moreover, clinical and preclinical investigations have revealed a marked sleep-related increase in the frequency of epileptic activities. This characteristic might provide clues to the pathophysiological pathways underlying this comorbidity. Furthermore, the preferential sleep-related occurrence of epileptic events opens up the possibility that they might hasten cognitive decline by interfering with the delicately orchestrated synchrony of oscillatory activities implicated in sleep-related memory consolidation. Therefore, we scrutinized the literature for mechanisms that might promote sleep-related epileptic activity in AD and, possibly dementia onset in epilepsy, and we also aimed to determine to what degree and through which processes such events might alter the progression of AD. Finally, we discuss the implications for patient care and try to identify a common basis for methodological considerations for future research and clinical practice. |
format | Online Article Text |
id | pubmed-9035794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90357942022-04-26 Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy B. Szabo, Anna Cretin, Benjamin Gérard, Fleur Curot, Jonathan J. Barbeau, Emmanuel Pariente, Jérémie Dahan, Lionel Valton, Luc Front Neurol Neurology The observation that a pathophysiological link might exist between Alzheimer's disease (AD) and epilepsy dates back to the identification of the first cases of the pathology itself and is now strongly supported by an ever-increasing mountain of literature. An overwhelming majority of data suggests not only a higher prevalence of epilepsy in Alzheimer's disease compared to healthy aging, but also that AD patients with a comorbid epileptic syndrome, even subclinical, have a steeper cognitive decline. Moreover, clinical and preclinical investigations have revealed a marked sleep-related increase in the frequency of epileptic activities. This characteristic might provide clues to the pathophysiological pathways underlying this comorbidity. Furthermore, the preferential sleep-related occurrence of epileptic events opens up the possibility that they might hasten cognitive decline by interfering with the delicately orchestrated synchrony of oscillatory activities implicated in sleep-related memory consolidation. Therefore, we scrutinized the literature for mechanisms that might promote sleep-related epileptic activity in AD and, possibly dementia onset in epilepsy, and we also aimed to determine to what degree and through which processes such events might alter the progression of AD. Finally, we discuss the implications for patient care and try to identify a common basis for methodological considerations for future research and clinical practice. Frontiers Media S.A. 2022-04-11 /pmc/articles/PMC9035794/ /pubmed/35481265 http://dx.doi.org/10.3389/fneur.2022.836292 Text en Copyright © 2022 B. Szabo, Cretin, Gérard, Curot, J. Barbeau, Pariente, Dahan and Valton. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology B. Szabo, Anna Cretin, Benjamin Gérard, Fleur Curot, Jonathan J. Barbeau, Emmanuel Pariente, Jérémie Dahan, Lionel Valton, Luc Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy |
title | Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy |
title_full | Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy |
title_fullStr | Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy |
title_full_unstemmed | Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy |
title_short | Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy |
title_sort | sleep: the tip of the iceberg in the bidirectional link between alzheimer's disease and epilepsy |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035794/ https://www.ncbi.nlm.nih.gov/pubmed/35481265 http://dx.doi.org/10.3389/fneur.2022.836292 |
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