Cargando…
PEGylated Domain I of Beta-2-Glycoprotein I Inhibits Thrombosis in a Chronic Mouse Model of the Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibodies cause clinical effects of vascular thrombosis and pregnancy morbidity. The only evidence-based treatments are anticoagulant medications such as warfarin and heparin. These medications have a number of disadvantages, no...
Autores principales: | Willis, Rohan, McDonnell, Thomas C. R., Pericleous, Charis, Gonzalez, Emilio B., Schleh, Alvaro, Romay-Penabad, Zurina, Giles, Ian P., Rahman, Anisur |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035797/ https://www.ncbi.nlm.nih.gov/pubmed/35479096 http://dx.doi.org/10.3389/fimmu.2022.842923 |
Ejemplares similares
-
PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome
por: McDonnell, Thomas C. R., et al.
Publicado: (2018) -
Antiphospholipid Antibodies to Domain I of Beta-2-Glycoprotein I Show Different Subclass Predominance in Comparison to Antibodies to Whole Beta-2-glycoprotein I
por: McDonnell, Thomas, et al.
Publicado: (2018) -
Antibodies to domain I of β-2-glycoprotein I and IgA antiphospholipid antibodies in patients with ‘seronegative’ antiphospholipid syndrome
por: Cousins, Laura, et al.
Publicado: (2015) -
Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β(2)-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis
por: Pericleous, Charis, et al.
Publicado: (2015) -
Development of a high yield expression and purification system for Domain I of Beta-2-glycoprotein I for the treatment of APS
por: McDonnell, Thomas, et al.
Publicado: (2015)