CpG Site-Specific Methylation-Modulated Divergent Expression of PRSS3 Transcript Variants Facilitates Nongenetic Intratumor Heterogeneity in Human Hepatocellular Carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most lethal human tumors with extensive intratumor heterogeneity (ITH). Serine protease 3 (PRSS3) is an indispensable member of the trypsin family and has been implicated in the pathogenesis of several malignancies, including HCC. However, the...

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Detalles Bibliográficos
Autores principales: Lin, Shuye, Xu, Hanli, Pang, Mengdi, Zhou, Xiaomeng, Pan, Yuanming, Zhang, Lishu, Guan, Xin, Wang, Xiaoyue, Lin, Bonan, Tian, Rongmeng, Chen, Keqiang, Zhang, Xiaochen, Yang, Zijiang, Ji, Fengmin, Huang, Yingying, Wei, Wu, Gong, Wanghua, Ren, Jianke, Wang, Ji Ming, Guo, Mingzhou, Huang, Jiaqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035874/
https://www.ncbi.nlm.nih.gov/pubmed/35480112
http://dx.doi.org/10.3389/fonc.2022.831268

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