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The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment

Diabetes is a chronic disease leading to memory difficulties and deterioration of learning abilities. The previous studies showed that modulation of inflammatory pathways in the diabetic brain may reduce dysfunction or cell death in brain areas which are important for control of cognitive function....

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Autores principales: Piątkowska-Chmiel, Iwona, Gawrońska-Grzywacz, Monika, Popiołek, Łukasz, Herbet, Mariola, Dudka, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035983/
https://www.ncbi.nlm.nih.gov/pubmed/35468904
http://dx.doi.org/10.1038/s41598-022-10187-y
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author Piątkowska-Chmiel, Iwona
Gawrońska-Grzywacz, Monika
Popiołek, Łukasz
Herbet, Mariola
Dudka, Jarosław
author_facet Piątkowska-Chmiel, Iwona
Gawrońska-Grzywacz, Monika
Popiołek, Łukasz
Herbet, Mariola
Dudka, Jarosław
author_sort Piątkowska-Chmiel, Iwona
collection PubMed
description Diabetes is a chronic disease leading to memory difficulties and deterioration of learning abilities. The previous studies showed that modulation of inflammatory pathways in the diabetic brain may reduce dysfunction or cell death in brain areas which are important for control of cognitive function. In the present study, we investigated the neuroprotective actions of newly synthesized adamantane derivatives on diabetes-induced cognitive impairment in mice. Our study relied on the fact that both vildagliptin and saxagliptin belong to DPP4 inhibitors and, contain adamantanyl group. Efficacy of tested compounds at reversing diabetes-induced different types of memory impairment was evaluated with the use of selected behavioural tests. The following neuroinflammatory indicators were also analyzed: neuroinflammatory indicators and the expression of genes involved in the inflammatory response of brain (Cav1, Bdnf). Our study demonstrated that new adamantane derivatives, similarly to DPP4 inhibitors, can restrict diabetes-induced cognitive deficits. We demonstrated that the overexpression of GLP-1-glucagon-like peptide as well as Bdnf, Cav1 genes translate into central blockade of pro-inflammatory synthesis of cytokines and significantly improvement on memory performance in diabetes mice. Newly synthesized adamantane derivatives might have important roles in prevention and treatment of cognitive impairment by inflammatory events in patients with diabetes or related diseases.
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spelling pubmed-90359832022-04-25 The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment Piątkowska-Chmiel, Iwona Gawrońska-Grzywacz, Monika Popiołek, Łukasz Herbet, Mariola Dudka, Jarosław Sci Rep Article Diabetes is a chronic disease leading to memory difficulties and deterioration of learning abilities. The previous studies showed that modulation of inflammatory pathways in the diabetic brain may reduce dysfunction or cell death in brain areas which are important for control of cognitive function. In the present study, we investigated the neuroprotective actions of newly synthesized adamantane derivatives on diabetes-induced cognitive impairment in mice. Our study relied on the fact that both vildagliptin and saxagliptin belong to DPP4 inhibitors and, contain adamantanyl group. Efficacy of tested compounds at reversing diabetes-induced different types of memory impairment was evaluated with the use of selected behavioural tests. The following neuroinflammatory indicators were also analyzed: neuroinflammatory indicators and the expression of genes involved in the inflammatory response of brain (Cav1, Bdnf). Our study demonstrated that new adamantane derivatives, similarly to DPP4 inhibitors, can restrict diabetes-induced cognitive deficits. We demonstrated that the overexpression of GLP-1-glucagon-like peptide as well as Bdnf, Cav1 genes translate into central blockade of pro-inflammatory synthesis of cytokines and significantly improvement on memory performance in diabetes mice. Newly synthesized adamantane derivatives might have important roles in prevention and treatment of cognitive impairment by inflammatory events in patients with diabetes or related diseases. Nature Publishing Group UK 2022-04-25 /pmc/articles/PMC9035983/ /pubmed/35468904 http://dx.doi.org/10.1038/s41598-022-10187-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Piątkowska-Chmiel, Iwona
Gawrońska-Grzywacz, Monika
Popiołek, Łukasz
Herbet, Mariola
Dudka, Jarosław
The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
title The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
title_full The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
title_fullStr The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
title_full_unstemmed The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
title_short The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
title_sort novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035983/
https://www.ncbi.nlm.nih.gov/pubmed/35468904
http://dx.doi.org/10.1038/s41598-022-10187-y
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