Cargando…
The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
Diabetes is a chronic disease leading to memory difficulties and deterioration of learning abilities. The previous studies showed that modulation of inflammatory pathways in the diabetic brain may reduce dysfunction or cell death in brain areas which are important for control of cognitive function....
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035983/ https://www.ncbi.nlm.nih.gov/pubmed/35468904 http://dx.doi.org/10.1038/s41598-022-10187-y |
_version_ | 1784693421743538176 |
---|---|
author | Piątkowska-Chmiel, Iwona Gawrońska-Grzywacz, Monika Popiołek, Łukasz Herbet, Mariola Dudka, Jarosław |
author_facet | Piątkowska-Chmiel, Iwona Gawrońska-Grzywacz, Monika Popiołek, Łukasz Herbet, Mariola Dudka, Jarosław |
author_sort | Piątkowska-Chmiel, Iwona |
collection | PubMed |
description | Diabetes is a chronic disease leading to memory difficulties and deterioration of learning abilities. The previous studies showed that modulation of inflammatory pathways in the diabetic brain may reduce dysfunction or cell death in brain areas which are important for control of cognitive function. In the present study, we investigated the neuroprotective actions of newly synthesized adamantane derivatives on diabetes-induced cognitive impairment in mice. Our study relied on the fact that both vildagliptin and saxagliptin belong to DPP4 inhibitors and, contain adamantanyl group. Efficacy of tested compounds at reversing diabetes-induced different types of memory impairment was evaluated with the use of selected behavioural tests. The following neuroinflammatory indicators were also analyzed: neuroinflammatory indicators and the expression of genes involved in the inflammatory response of brain (Cav1, Bdnf). Our study demonstrated that new adamantane derivatives, similarly to DPP4 inhibitors, can restrict diabetes-induced cognitive deficits. We demonstrated that the overexpression of GLP-1-glucagon-like peptide as well as Bdnf, Cav1 genes translate into central blockade of pro-inflammatory synthesis of cytokines and significantly improvement on memory performance in diabetes mice. Newly synthesized adamantane derivatives might have important roles in prevention and treatment of cognitive impairment by inflammatory events in patients with diabetes or related diseases. |
format | Online Article Text |
id | pubmed-9035983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90359832022-04-25 The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment Piątkowska-Chmiel, Iwona Gawrońska-Grzywacz, Monika Popiołek, Łukasz Herbet, Mariola Dudka, Jarosław Sci Rep Article Diabetes is a chronic disease leading to memory difficulties and deterioration of learning abilities. The previous studies showed that modulation of inflammatory pathways in the diabetic brain may reduce dysfunction or cell death in brain areas which are important for control of cognitive function. In the present study, we investigated the neuroprotective actions of newly synthesized adamantane derivatives on diabetes-induced cognitive impairment in mice. Our study relied on the fact that both vildagliptin and saxagliptin belong to DPP4 inhibitors and, contain adamantanyl group. Efficacy of tested compounds at reversing diabetes-induced different types of memory impairment was evaluated with the use of selected behavioural tests. The following neuroinflammatory indicators were also analyzed: neuroinflammatory indicators and the expression of genes involved in the inflammatory response of brain (Cav1, Bdnf). Our study demonstrated that new adamantane derivatives, similarly to DPP4 inhibitors, can restrict diabetes-induced cognitive deficits. We demonstrated that the overexpression of GLP-1-glucagon-like peptide as well as Bdnf, Cav1 genes translate into central blockade of pro-inflammatory synthesis of cytokines and significantly improvement on memory performance in diabetes mice. Newly synthesized adamantane derivatives might have important roles in prevention and treatment of cognitive impairment by inflammatory events in patients with diabetes or related diseases. Nature Publishing Group UK 2022-04-25 /pmc/articles/PMC9035983/ /pubmed/35468904 http://dx.doi.org/10.1038/s41598-022-10187-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Piątkowska-Chmiel, Iwona Gawrońska-Grzywacz, Monika Popiołek, Łukasz Herbet, Mariola Dudka, Jarosław The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment |
title | The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment |
title_full | The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment |
title_fullStr | The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment |
title_full_unstemmed | The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment |
title_short | The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment |
title_sort | novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035983/ https://www.ncbi.nlm.nih.gov/pubmed/35468904 http://dx.doi.org/10.1038/s41598-022-10187-y |
work_keys_str_mv | AT piatkowskachmieliwona thenoveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT gawronskagrzywaczmonika thenoveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT popiołekłukasz thenoveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT herbetmariola thenoveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT dudkajarosław thenoveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT piatkowskachmieliwona noveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT gawronskagrzywaczmonika noveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT popiołekłukasz noveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT herbetmariola noveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment AT dudkajarosław noveladamantanederivativesaspotentialmediatorsofinflammationandneuralplasticityindiabetesmicewithcognitiveimpairment |