Cargando…
Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration
Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial heali...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036008/ https://www.ncbi.nlm.nih.gov/pubmed/35218328 http://dx.doi.org/10.1002/advs.202102220 |
_version_ | 1784693428074840064 |
---|---|
author | Dong, Chenle Yang, Chen Younis, Muhammad Rizwan Zhang, Jing He, Gang Qiu, Xingdi Fu, Lian‐Hua Zhang, Dong‐Yang Wang, Hao Hong, Wenli Lin, Jing Wu, Xueqing Huang, Peng |
author_facet | Dong, Chenle Yang, Chen Younis, Muhammad Rizwan Zhang, Jing He, Gang Qiu, Xingdi Fu, Lian‐Hua Zhang, Dong‐Yang Wang, Hao Hong, Wenli Lin, Jing Wu, Xueqing Huang, Peng |
author_sort | Dong, Chenle |
collection | PubMed |
description | Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near‐infrared (NIR‐II) light‐responsive shape memory composite based on the combination of cuprorivaite (CaCuSi(4)O(10)) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly(d,l‐lactide‐co‐trimethylene carbonate) (PT) as shape memory building blocks is developed. The as‐prepared CUP/PT composite possesses excellent shape memory performance under NIR‐II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability. |
format | Online Article Text |
id | pubmed-9036008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90360082022-04-27 Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration Dong, Chenle Yang, Chen Younis, Muhammad Rizwan Zhang, Jing He, Gang Qiu, Xingdi Fu, Lian‐Hua Zhang, Dong‐Yang Wang, Hao Hong, Wenli Lin, Jing Wu, Xueqing Huang, Peng Adv Sci (Weinh) Research Articles Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near‐infrared (NIR‐II) light‐responsive shape memory composite based on the combination of cuprorivaite (CaCuSi(4)O(10)) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly(d,l‐lactide‐co‐trimethylene carbonate) (PT) as shape memory building blocks is developed. The as‐prepared CUP/PT composite possesses excellent shape memory performance under NIR‐II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability. John Wiley and Sons Inc. 2022-02-26 /pmc/articles/PMC9036008/ /pubmed/35218328 http://dx.doi.org/10.1002/advs.202102220 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Dong, Chenle Yang, Chen Younis, Muhammad Rizwan Zhang, Jing He, Gang Qiu, Xingdi Fu, Lian‐Hua Zhang, Dong‐Yang Wang, Hao Hong, Wenli Lin, Jing Wu, Xueqing Huang, Peng Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration |
title | Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration |
title_full | Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration |
title_fullStr | Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration |
title_full_unstemmed | Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration |
title_short | Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration |
title_sort | bioactive nir‐ii light‐responsive shape memory composite based on cuprorivaite nanosheets for endometrial regeneration |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036008/ https://www.ncbi.nlm.nih.gov/pubmed/35218328 http://dx.doi.org/10.1002/advs.202102220 |
work_keys_str_mv | AT dongchenle bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT yangchen bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT younismuhammadrizwan bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT zhangjing bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT hegang bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT qiuxingdi bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT fulianhua bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT zhangdongyang bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT wanghao bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT hongwenli bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT linjing bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT wuxueqing bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration AT huangpeng bioactiveniriilightresponsiveshapememorycompositebasedoncuprorivaitenanosheetsforendometrialregeneration |