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Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation
Current pharmacotherapy is challenged by side effects and drug resistance issues due to the lack of drug selectivity. Mechanochemistry‐based strategies provide new avenues to overcome the related problems by improving drug selectivity. It is recently shown that sonomechanical bond scission enables t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036040/ https://www.ncbi.nlm.nih.gov/pubmed/35195372 http://dx.doi.org/10.1002/advs.202104696 |
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author | Huo, Shuaidong Liao, Zhihuan Zhao, Pengkun Zhou, Yu Göstl, Robert Herrmann, Andreas |
author_facet | Huo, Shuaidong Liao, Zhihuan Zhao, Pengkun Zhou, Yu Göstl, Robert Herrmann, Andreas |
author_sort | Huo, Shuaidong |
collection | PubMed |
description | Current pharmacotherapy is challenged by side effects and drug resistance issues due to the lack of drug selectivity. Mechanochemistry‐based strategies provide new avenues to overcome the related problems by improving drug selectivity. It is recently shown that sonomechanical bond scission enables the remote‐controlled drug release from their inactive parent macromolecules using ultrasound (US). To further expand the scope of the US‐controlled drug activation strategy, herein a mechano‐responsive nanoswitch for the selective activation of doxorubicin (DOX) to inhibit cancer cell proliferation is constructed. As a proof‐of‐concept, the synthesis, characterization, and US‐responsive drug activation evaluation of the mechano‐nanoswitch, which provides a blueprint for tailoring nanosystems for force‐induced pharmacotherapy is presented. |
format | Online Article Text |
id | pubmed-9036040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90360402022-04-27 Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation Huo, Shuaidong Liao, Zhihuan Zhao, Pengkun Zhou, Yu Göstl, Robert Herrmann, Andreas Adv Sci (Weinh) Research Articles Current pharmacotherapy is challenged by side effects and drug resistance issues due to the lack of drug selectivity. Mechanochemistry‐based strategies provide new avenues to overcome the related problems by improving drug selectivity. It is recently shown that sonomechanical bond scission enables the remote‐controlled drug release from their inactive parent macromolecules using ultrasound (US). To further expand the scope of the US‐controlled drug activation strategy, herein a mechano‐responsive nanoswitch for the selective activation of doxorubicin (DOX) to inhibit cancer cell proliferation is constructed. As a proof‐of‐concept, the synthesis, characterization, and US‐responsive drug activation evaluation of the mechano‐nanoswitch, which provides a blueprint for tailoring nanosystems for force‐induced pharmacotherapy is presented. John Wiley and Sons Inc. 2022-02-23 /pmc/articles/PMC9036040/ /pubmed/35195372 http://dx.doi.org/10.1002/advs.202104696 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Huo, Shuaidong Liao, Zhihuan Zhao, Pengkun Zhou, Yu Göstl, Robert Herrmann, Andreas Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation |
title | Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation |
title_full | Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation |
title_fullStr | Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation |
title_full_unstemmed | Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation |
title_short | Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation |
title_sort | mechano‐nanoswitches for ultrasound‐controlled drug activation |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036040/ https://www.ncbi.nlm.nih.gov/pubmed/35195372 http://dx.doi.org/10.1002/advs.202104696 |
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