Cargando…

Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation

Current pharmacotherapy is challenged by side effects and drug resistance issues due to the lack of drug selectivity. Mechanochemistry‐based strategies provide new avenues to overcome the related problems by improving drug selectivity. It is recently shown that sonomechanical bond scission enables t...

Descripción completa

Detalles Bibliográficos
Autores principales: Huo, Shuaidong, Liao, Zhihuan, Zhao, Pengkun, Zhou, Yu, Göstl, Robert, Herrmann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036040/
https://www.ncbi.nlm.nih.gov/pubmed/35195372
http://dx.doi.org/10.1002/advs.202104696
_version_ 1784693435943354368
author Huo, Shuaidong
Liao, Zhihuan
Zhao, Pengkun
Zhou, Yu
Göstl, Robert
Herrmann, Andreas
author_facet Huo, Shuaidong
Liao, Zhihuan
Zhao, Pengkun
Zhou, Yu
Göstl, Robert
Herrmann, Andreas
author_sort Huo, Shuaidong
collection PubMed
description Current pharmacotherapy is challenged by side effects and drug resistance issues due to the lack of drug selectivity. Mechanochemistry‐based strategies provide new avenues to overcome the related problems by improving drug selectivity. It is recently shown that sonomechanical bond scission enables the remote‐controlled drug release from their inactive parent macromolecules using ultrasound (US). To further expand the scope of the US‐controlled drug activation strategy, herein a mechano‐responsive nanoswitch for the selective activation of doxorubicin (DOX) to inhibit cancer cell proliferation is constructed. As a proof‐of‐concept, the synthesis, characterization, and US‐responsive drug activation evaluation of the mechano‐nanoswitch, which provides a blueprint for tailoring nanosystems for force‐induced pharmacotherapy is presented.
format Online
Article
Text
id pubmed-9036040
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-90360402022-04-27 Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation Huo, Shuaidong Liao, Zhihuan Zhao, Pengkun Zhou, Yu Göstl, Robert Herrmann, Andreas Adv Sci (Weinh) Research Articles Current pharmacotherapy is challenged by side effects and drug resistance issues due to the lack of drug selectivity. Mechanochemistry‐based strategies provide new avenues to overcome the related problems by improving drug selectivity. It is recently shown that sonomechanical bond scission enables the remote‐controlled drug release from their inactive parent macromolecules using ultrasound (US). To further expand the scope of the US‐controlled drug activation strategy, herein a mechano‐responsive nanoswitch for the selective activation of doxorubicin (DOX) to inhibit cancer cell proliferation is constructed. As a proof‐of‐concept, the synthesis, characterization, and US‐responsive drug activation evaluation of the mechano‐nanoswitch, which provides a blueprint for tailoring nanosystems for force‐induced pharmacotherapy is presented. John Wiley and Sons Inc. 2022-02-23 /pmc/articles/PMC9036040/ /pubmed/35195372 http://dx.doi.org/10.1002/advs.202104696 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Huo, Shuaidong
Liao, Zhihuan
Zhao, Pengkun
Zhou, Yu
Göstl, Robert
Herrmann, Andreas
Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation
title Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation
title_full Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation
title_fullStr Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation
title_full_unstemmed Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation
title_short Mechano‐Nanoswitches for Ultrasound‐Controlled Drug Activation
title_sort mechano‐nanoswitches for ultrasound‐controlled drug activation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036040/
https://www.ncbi.nlm.nih.gov/pubmed/35195372
http://dx.doi.org/10.1002/advs.202104696
work_keys_str_mv AT huoshuaidong mechanonanoswitchesforultrasoundcontrolleddrugactivation
AT liaozhihuan mechanonanoswitchesforultrasoundcontrolleddrugactivation
AT zhaopengkun mechanonanoswitchesforultrasoundcontrolleddrugactivation
AT zhouyu mechanonanoswitchesforultrasoundcontrolleddrugactivation
AT gostlrobert mechanonanoswitchesforultrasoundcontrolleddrugactivation
AT herrmannandreas mechanonanoswitchesforultrasoundcontrolleddrugactivation