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Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022)

Alleviating Acute Kidney Injury In article number 2103675, Ying Chen, Fan Bai, Li Yang, and co‐workers revealed S100a8/a9(high) infiltrated macrophage initiated and amplified inflammation in acute kidney injury. The “Comets” represent S100a8/a9(high) infiltrated macrophages which derive from bone ma...

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Detalles Bibliográficos
Autores principales: Yao, Weijian, Chen, Ying, Li, Zehua, Ji, Jing, You, Abin, Jin, Shanzhao, Ma, Yuan, Zhao, Youlu, Wang, Jinwei, Qu, Lei, Wang, Hui, Xiang, Chengang, Wang, Suxia, Liu, Gang, Bai, Fan, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036045/
http://dx.doi.org/10.1002/advs.202270079
Descripción
Sumario:Alleviating Acute Kidney Injury In article number 2103675, Ying Chen, Fan Bai, Li Yang, and co‐workers revealed S100a8/a9(high) infiltrated macrophage initiated and amplified inflammation in acute kidney injury. The “Comets” represent S100a8/a9(high) infiltrated macrophages which derive from bone marrow, response the earliest to the signals sent by the injured kidney, infiltrate and cause further damage to the kidney (the kidney with flame). Two small molecule drugs (little cartoon people in light or dark blue color) which specifically inhibit S100a8/a9, could reduce renal inflammation and protect kidney from acute injury (the kidney without flame). [Image: see text]