Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022)

Alleviating Acute Kidney Injury In article number 2103675, Ying Chen, Fan Bai, Li Yang, and co‐workers revealed S100a8/a9(high) infiltrated macrophage initiated and amplified inflammation in acute kidney injury. The “Comets” represent S100a8/a9(high) infiltrated macrophages which derive from bone ma...

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Autores principales: Yao, Weijian, Chen, Ying, Li, Zehua, Ji, Jing, You, Abin, Jin, Shanzhao, Ma, Yuan, Zhao, Youlu, Wang, Jinwei, Qu, Lei, Wang, Hui, Xiang, Chengang, Wang, Suxia, Liu, Gang, Bai, Fan, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036045/
http://dx.doi.org/10.1002/advs.202270079
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author Yao, Weijian
Chen, Ying
Li, Zehua
Ji, Jing
You, Abin
Jin, Shanzhao
Ma, Yuan
Zhao, Youlu
Wang, Jinwei
Qu, Lei
Wang, Hui
Xiang, Chengang
Wang, Suxia
Liu, Gang
Bai, Fan
Yang, Li
author_facet Yao, Weijian
Chen, Ying
Li, Zehua
Ji, Jing
You, Abin
Jin, Shanzhao
Ma, Yuan
Zhao, Youlu
Wang, Jinwei
Qu, Lei
Wang, Hui
Xiang, Chengang
Wang, Suxia
Liu, Gang
Bai, Fan
Yang, Li
author_sort Yao, Weijian
collection PubMed
description Alleviating Acute Kidney Injury In article number 2103675, Ying Chen, Fan Bai, Li Yang, and co‐workers revealed S100a8/a9(high) infiltrated macrophage initiated and amplified inflammation in acute kidney injury. The “Comets” represent S100a8/a9(high) infiltrated macrophages which derive from bone marrow, response the earliest to the signals sent by the injured kidney, infiltrate and cause further damage to the kidney (the kidney with flame). Two small molecule drugs (little cartoon people in light or dark blue color) which specifically inhibit S100a8/a9, could reduce renal inflammation and protect kidney from acute injury (the kidney without flame). [Image: see text]
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spelling pubmed-90360452022-04-27 Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022) Yao, Weijian Chen, Ying Li, Zehua Ji, Jing You, Abin Jin, Shanzhao Ma, Yuan Zhao, Youlu Wang, Jinwei Qu, Lei Wang, Hui Xiang, Chengang Wang, Suxia Liu, Gang Bai, Fan Yang, Li Adv Sci (Weinh) Back Cover Alleviating Acute Kidney Injury In article number 2103675, Ying Chen, Fan Bai, Li Yang, and co‐workers revealed S100a8/a9(high) infiltrated macrophage initiated and amplified inflammation in acute kidney injury. The “Comets” represent S100a8/a9(high) infiltrated macrophages which derive from bone marrow, response the earliest to the signals sent by the injured kidney, infiltrate and cause further damage to the kidney (the kidney with flame). Two small molecule drugs (little cartoon people in light or dark blue color) which specifically inhibit S100a8/a9, could reduce renal inflammation and protect kidney from acute injury (the kidney without flame). [Image: see text] John Wiley and Sons Inc. 2022-04-25 /pmc/articles/PMC9036045/ http://dx.doi.org/10.1002/advs.202270079 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Back Cover
Yao, Weijian
Chen, Ying
Li, Zehua
Ji, Jing
You, Abin
Jin, Shanzhao
Ma, Yuan
Zhao, Youlu
Wang, Jinwei
Qu, Lei
Wang, Hui
Xiang, Chengang
Wang, Suxia
Liu, Gang
Bai, Fan
Yang, Li
Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022)
title Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022)
title_full Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022)
title_fullStr Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022)
title_full_unstemmed Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022)
title_short Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury (Adv. Sci. 12/2022)
title_sort single cell rna sequencing identifies a unique inflammatory macrophage subset as a druggable target for alleviating acute kidney injury (adv. sci. 12/2022)
topic Back Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036045/
http://dx.doi.org/10.1002/advs.202270079
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