An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiting LPL. We also recently showed that the TG-loweri...

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Detalles Bibliográficos
Autores principales: Balasubramaniam, Deepa, Schroeder, Oliver, Russell, Anna M., Fitchett, Jonathan R., Austin, Aaron K., Beyer, Thomas P., Chen, Yan Q., Day, Jonathan W., Ehsani, Mariam, Heng, Aik Roy, Zhen, Eugene Y., Davies, Julian, Glaesner, Wolfgang, Jones, Bryan E., Siegel, Robert W., Qian, Yue-Wei, Konrad, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036128/
https://www.ncbi.nlm.nih.gov/pubmed/35307397
http://dx.doi.org/10.1016/j.jlr.2022.100198

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