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Regulatory Role of Host MicroRNAs in Flaviviruses Infection

MicroRNAs (miRNAs) are small non-coding RNA that affect mRNA abundance or translation efficiency by binding to the 3′UTR of the mRNA of the target gene, thereby participating in multiple biological processes, including viral infection. Flavivirus genus consists of small, positive-stranded, single-st...

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Autores principales: Cai, Wenjun, Pan, Yuhong, Cheng, Anchun, Wang, Mingshu, Yin, Zhongqiong, Jia, Renyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036177/
https://www.ncbi.nlm.nih.gov/pubmed/35479613
http://dx.doi.org/10.3389/fmicb.2022.869441
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author Cai, Wenjun
Pan, Yuhong
Cheng, Anchun
Wang, Mingshu
Yin, Zhongqiong
Jia, Renyong
author_facet Cai, Wenjun
Pan, Yuhong
Cheng, Anchun
Wang, Mingshu
Yin, Zhongqiong
Jia, Renyong
author_sort Cai, Wenjun
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNA that affect mRNA abundance or translation efficiency by binding to the 3′UTR of the mRNA of the target gene, thereby participating in multiple biological processes, including viral infection. Flavivirus genus consists of small, positive-stranded, single-stranded RNA viruses transmitted by arthropods, especially mosquitoes and ticks. The genus contains several globally significant human/animal pathogens, such as Dengue virus, Japanese encephalitis virus, West Nile virus, Zika virus, Yellow fever virus, Tick-borne encephalitis virus, and Tembusu virus. After flavivirus invades, the expression of host miRNA changes, exerting the immune escape mechanism to create an environment conducive to its survival, and the altered miRNA in turn affects the life cycle of the virus. Accumulated evidence suggests that host miRNAs influence flavivirus replication and host–virus interactions through direct binding of viral genomes or through virus-mediated host transcriptome changes. Furthermore, miRNA can also interweave with other non-coding RNAs, such as long non-coding RNA and circular RNA, to form an interaction network to regulate viral replication. A variety of non-coding RNAs produced by the virus itself exert similar function by interacting with cellular RNA and viral RNA. Understanding the interaction sites between non-coding RNA, especially miRNA, and virus/host genes will help us to find targets for antiviral drugs and viral therapy.
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spelling pubmed-90361772022-04-26 Regulatory Role of Host MicroRNAs in Flaviviruses Infection Cai, Wenjun Pan, Yuhong Cheng, Anchun Wang, Mingshu Yin, Zhongqiong Jia, Renyong Front Microbiol Microbiology MicroRNAs (miRNAs) are small non-coding RNA that affect mRNA abundance or translation efficiency by binding to the 3′UTR of the mRNA of the target gene, thereby participating in multiple biological processes, including viral infection. Flavivirus genus consists of small, positive-stranded, single-stranded RNA viruses transmitted by arthropods, especially mosquitoes and ticks. The genus contains several globally significant human/animal pathogens, such as Dengue virus, Japanese encephalitis virus, West Nile virus, Zika virus, Yellow fever virus, Tick-borne encephalitis virus, and Tembusu virus. After flavivirus invades, the expression of host miRNA changes, exerting the immune escape mechanism to create an environment conducive to its survival, and the altered miRNA in turn affects the life cycle of the virus. Accumulated evidence suggests that host miRNAs influence flavivirus replication and host–virus interactions through direct binding of viral genomes or through virus-mediated host transcriptome changes. Furthermore, miRNA can also interweave with other non-coding RNAs, such as long non-coding RNA and circular RNA, to form an interaction network to regulate viral replication. A variety of non-coding RNAs produced by the virus itself exert similar function by interacting with cellular RNA and viral RNA. Understanding the interaction sites between non-coding RNA, especially miRNA, and virus/host genes will help us to find targets for antiviral drugs and viral therapy. Frontiers Media S.A. 2022-04-11 /pmc/articles/PMC9036177/ /pubmed/35479613 http://dx.doi.org/10.3389/fmicb.2022.869441 Text en Copyright © 2022 Cai, Pan, Cheng, Wang, Yin and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Cai, Wenjun
Pan, Yuhong
Cheng, Anchun
Wang, Mingshu
Yin, Zhongqiong
Jia, Renyong
Regulatory Role of Host MicroRNAs in Flaviviruses Infection
title Regulatory Role of Host MicroRNAs in Flaviviruses Infection
title_full Regulatory Role of Host MicroRNAs in Flaviviruses Infection
title_fullStr Regulatory Role of Host MicroRNAs in Flaviviruses Infection
title_full_unstemmed Regulatory Role of Host MicroRNAs in Flaviviruses Infection
title_short Regulatory Role of Host MicroRNAs in Flaviviruses Infection
title_sort regulatory role of host micrornas in flaviviruses infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036177/
https://www.ncbi.nlm.nih.gov/pubmed/35479613
http://dx.doi.org/10.3389/fmicb.2022.869441
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