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Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors

The endocrine disruptors are mostly small organic molecules developed for numerous and very diverse industrial applications. They essentially act through nuclear receptors with small and hydrophobic endogenous ligands. Nevertheless, potential adverse effects through membrane hormone receptors cannot...

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Autores principales: Combarnous, Yves, Nguyen, Thi Mong Diep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036253/
https://www.ncbi.nlm.nih.gov/pubmed/35466213
http://dx.doi.org/10.3390/jox12020007
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author Combarnous, Yves
Nguyen, Thi Mong Diep
author_facet Combarnous, Yves
Nguyen, Thi Mong Diep
author_sort Combarnous, Yves
collection PubMed
description The endocrine disruptors are mostly small organic molecules developed for numerous and very diverse industrial applications. They essentially act through nuclear receptors with small and hydrophobic endogenous ligands. Nevertheless, potential adverse effects through membrane hormone receptors cannot be ruled out, and have indeed been observed. The present paper reviews how orthosteric and allosteric binding sites of the different families of membrane receptors can be targets for man-made hydrophobic molecules (components of plastics, paints, flame retardants, herbicides, pesticides, etc.). We also review potential target proteins for such small hydrophobic molecules downstream of membrane receptors at the level of their intracellular signaling pathways. From the currently available information, although endocrine disruptors primarily affect nuclear receptors’ signaling, membrane receptors for hormones, cytokines, neuro-mediators, and growth factors can be affected as well and deserve attention.
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spelling pubmed-90362532022-04-26 Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors Combarnous, Yves Nguyen, Thi Mong Diep J Xenobiot Review The endocrine disruptors are mostly small organic molecules developed for numerous and very diverse industrial applications. They essentially act through nuclear receptors with small and hydrophobic endogenous ligands. Nevertheless, potential adverse effects through membrane hormone receptors cannot be ruled out, and have indeed been observed. The present paper reviews how orthosteric and allosteric binding sites of the different families of membrane receptors can be targets for man-made hydrophobic molecules (components of plastics, paints, flame retardants, herbicides, pesticides, etc.). We also review potential target proteins for such small hydrophobic molecules downstream of membrane receptors at the level of their intracellular signaling pathways. From the currently available information, although endocrine disruptors primarily affect nuclear receptors’ signaling, membrane receptors for hormones, cytokines, neuro-mediators, and growth factors can be affected as well and deserve attention. MDPI 2022-03-25 /pmc/articles/PMC9036253/ /pubmed/35466213 http://dx.doi.org/10.3390/jox12020007 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Combarnous, Yves
Nguyen, Thi Mong Diep
Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
title Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
title_full Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
title_fullStr Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
title_full_unstemmed Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
title_short Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
title_sort membrane hormone receptors and their signaling pathways as targets for endocrine disruptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036253/
https://www.ncbi.nlm.nih.gov/pubmed/35466213
http://dx.doi.org/10.3390/jox12020007
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