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Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?

BACKGROUND: In clinical practice, distinguishing disease activity in patients with rheumatological illnesses is challenging. OBJECTIVES: We aimed to investigate clinical associations of hemogram-derived indices, namely: red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lym...

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Autores principales: Taha, Sara I, Samaan, Sara F, Ibrahim, Rehab Ali, Moustafa, Nouran M, El-Sehsah, Eman M, Youssef, Mariam K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036329/
https://www.ncbi.nlm.nih.gov/pubmed/35481333
http://dx.doi.org/10.1177/11795441221089182
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author Taha, Sara I
Samaan, Sara F
Ibrahim, Rehab Ali
Moustafa, Nouran M
El-Sehsah, Eman M
Youssef, Mariam K
author_facet Taha, Sara I
Samaan, Sara F
Ibrahim, Rehab Ali
Moustafa, Nouran M
El-Sehsah, Eman M
Youssef, Mariam K
author_sort Taha, Sara I
collection PubMed
description BACKGROUND: In clinical practice, distinguishing disease activity in patients with rheumatological illnesses is challenging. OBJECTIVES: We aimed to investigate clinical associations of hemogram-derived indices, namely: red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) with disease activity in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). METHODS: In 250 patients with rheumatological disease and 100 healthy age-matched controls, we investigated disease activity scores and indicators and evaluated their association with hemogram-derived indices values. RESULTS: Compared with the control group, RDW, MPV, and PLR significantly increased (P < .001) in the three studied disorders (RA, SLE, and AS), but LMR dramatically decreased. SII was considerably higher in RA and AS patients compared with controls but not in SLE patients. On the other hand, NLR rose dramatically in SLE patients compared with controls (P = .043), but did not change much in RA and AS patients (P > .05). RDW and MPV showed significant changes (P < .001) in the three studied diseases (RA, SLE, and AS) according to disease activity. They significantly increased across worsening activity scores. Only in the SLE group, PLR was significantly increased with disease activity (P < .001), while LMR showed a significant decrease (P = .016). CONCLUSIONS: Clinicians must pay close attention to complete blood count (CBC) analysis and its various derived ratios to better characterize the activity of rheumatological disorders and anticipate the disease course and prognosis.
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spelling pubmed-90363292022-04-26 Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases? Taha, Sara I Samaan, Sara F Ibrahim, Rehab Ali Moustafa, Nouran M El-Sehsah, Eman M Youssef, Mariam K Clin Med Insights Arthritis Musculoskelet Disord Original Research BACKGROUND: In clinical practice, distinguishing disease activity in patients with rheumatological illnesses is challenging. OBJECTIVES: We aimed to investigate clinical associations of hemogram-derived indices, namely: red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) with disease activity in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). METHODS: In 250 patients with rheumatological disease and 100 healthy age-matched controls, we investigated disease activity scores and indicators and evaluated their association with hemogram-derived indices values. RESULTS: Compared with the control group, RDW, MPV, and PLR significantly increased (P < .001) in the three studied disorders (RA, SLE, and AS), but LMR dramatically decreased. SII was considerably higher in RA and AS patients compared with controls but not in SLE patients. On the other hand, NLR rose dramatically in SLE patients compared with controls (P = .043), but did not change much in RA and AS patients (P > .05). RDW and MPV showed significant changes (P < .001) in the three studied diseases (RA, SLE, and AS) according to disease activity. They significantly increased across worsening activity scores. Only in the SLE group, PLR was significantly increased with disease activity (P < .001), while LMR showed a significant decrease (P = .016). CONCLUSIONS: Clinicians must pay close attention to complete blood count (CBC) analysis and its various derived ratios to better characterize the activity of rheumatological disorders and anticipate the disease course and prognosis. SAGE Publications 2022-04-22 /pmc/articles/PMC9036329/ /pubmed/35481333 http://dx.doi.org/10.1177/11795441221089182 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Taha, Sara I
Samaan, Sara F
Ibrahim, Rehab Ali
Moustafa, Nouran M
El-Sehsah, Eman M
Youssef, Mariam K
Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?
title Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?
title_full Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?
title_fullStr Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?
title_full_unstemmed Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?
title_short Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?
title_sort can complete blood count picture tell us more about the activity of rheumatological diseases?
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036329/
https://www.ncbi.nlm.nih.gov/pubmed/35481333
http://dx.doi.org/10.1177/11795441221089182
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