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Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis

Pernicious anemia (PA) is a megaloblastic anemia consisting of hematological, gastric and immunological alterations. The immunopathogenesis of PA is sustained by both autoantibodies (e.g. intrinsic factor (IFA) antibodies and anti parietal cell (PCA) antibodies and autoreactive T cells specific for...

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Autores principales: Della Bella, Chiara, Antico, Antonio, Panozzo, Maria Piera, Capitani, Nagaja, Benagiano, Marisa, Petrone, Luisa, Azzurri, Annalisa, Pratesi, Sara, D’Elios, Sofia, Cianchi, Fabio, Ortiz-Princz, Diana, Bizzaro, Nicola, D’Elios, Mario Milco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036483/
https://www.ncbi.nlm.nih.gov/pubmed/35479078
http://dx.doi.org/10.3389/fimmu.2022.887256
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author Della Bella, Chiara
Antico, Antonio
Panozzo, Maria Piera
Capitani, Nagaja
Benagiano, Marisa
Petrone, Luisa
Azzurri, Annalisa
Pratesi, Sara
D’Elios, Sofia
Cianchi, Fabio
Ortiz-Princz, Diana
Bizzaro, Nicola
D’Elios, Mario Milco
author_facet Della Bella, Chiara
Antico, Antonio
Panozzo, Maria Piera
Capitani, Nagaja
Benagiano, Marisa
Petrone, Luisa
Azzurri, Annalisa
Pratesi, Sara
D’Elios, Sofia
Cianchi, Fabio
Ortiz-Princz, Diana
Bizzaro, Nicola
D’Elios, Mario Milco
author_sort Della Bella, Chiara
collection PubMed
description Pernicious anemia (PA) is a megaloblastic anemia consisting of hematological, gastric and immunological alterations. The immunopathogenesis of PA is sustained by both autoantibodies (e.g. intrinsic factor (IFA) antibodies and anti parietal cell (PCA) antibodies and autoreactive T cells specific for IFA and the parietal cell proton pump ATPase. Iron deficient anemia (IDA) is a microcytic anemia and represents the most common cause of anemia worldwide. Our work aimed to investigate serum levels of several interleukins (IL) of the IL-20 cytokine subfamily in patients with PA, with IDA and in healthy subjects (HC). We compared serum levels of IL-19, IL-20, IL-26, IL-28A and IL-29 in 43 patients with PA and autoimmune gastritis, in 20 patients with IDA and no autoimmune gastritis, and in 47 HC. Furthermore, we analyzed the IL-19 cytokine production by gastric lamina propria mononuclear cells (LPMC) in eight patients with PA and four HC. We found that patients with PA have significantly higher serum levels of IL-19 (163.68 ± 75.96 pg/ml) than patients with IDA (35.49 ± 40.97 pg/ml; p<0.001) and healthy subjects (55.68 ± 36.75 pg/ml; p<0.001). Gastric LPMC from all PA patients were able to produce significantly higher levels of IL-19 (420.67 ± 68.14 pg/ml) than HC (53.69 ± 10.92 pg/ml) (p<0.01). Altogether, our results indicate that IL-19 serum levels are significantly increased in patients with PA but not with IDA and that IL-19 is produced in vivo in the stomach of PA patients. These data open a new perspective on PA pathogenesis and suggest that IL-19 may represent a novel important tool for the management of patients with PA.
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spelling pubmed-90364832022-04-26 Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis Della Bella, Chiara Antico, Antonio Panozzo, Maria Piera Capitani, Nagaja Benagiano, Marisa Petrone, Luisa Azzurri, Annalisa Pratesi, Sara D’Elios, Sofia Cianchi, Fabio Ortiz-Princz, Diana Bizzaro, Nicola D’Elios, Mario Milco Front Immunol Immunology Pernicious anemia (PA) is a megaloblastic anemia consisting of hematological, gastric and immunological alterations. The immunopathogenesis of PA is sustained by both autoantibodies (e.g. intrinsic factor (IFA) antibodies and anti parietal cell (PCA) antibodies and autoreactive T cells specific for IFA and the parietal cell proton pump ATPase. Iron deficient anemia (IDA) is a microcytic anemia and represents the most common cause of anemia worldwide. Our work aimed to investigate serum levels of several interleukins (IL) of the IL-20 cytokine subfamily in patients with PA, with IDA and in healthy subjects (HC). We compared serum levels of IL-19, IL-20, IL-26, IL-28A and IL-29 in 43 patients with PA and autoimmune gastritis, in 20 patients with IDA and no autoimmune gastritis, and in 47 HC. Furthermore, we analyzed the IL-19 cytokine production by gastric lamina propria mononuclear cells (LPMC) in eight patients with PA and four HC. We found that patients with PA have significantly higher serum levels of IL-19 (163.68 ± 75.96 pg/ml) than patients with IDA (35.49 ± 40.97 pg/ml; p<0.001) and healthy subjects (55.68 ± 36.75 pg/ml; p<0.001). Gastric LPMC from all PA patients were able to produce significantly higher levels of IL-19 (420.67 ± 68.14 pg/ml) than HC (53.69 ± 10.92 pg/ml) (p<0.01). Altogether, our results indicate that IL-19 serum levels are significantly increased in patients with PA but not with IDA and that IL-19 is produced in vivo in the stomach of PA patients. These data open a new perspective on PA pathogenesis and suggest that IL-19 may represent a novel important tool for the management of patients with PA. Frontiers Media S.A. 2022-04-11 /pmc/articles/PMC9036483/ /pubmed/35479078 http://dx.doi.org/10.3389/fimmu.2022.887256 Text en Copyright © 2022 Della Bella, Antico, Panozzo, Capitani, Benagiano, Petrone, Azzurri, Pratesi, D’Elios, Cianchi, Ortiz-Princz, Bizzaro and D’Elios https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Della Bella, Chiara
Antico, Antonio
Panozzo, Maria Piera
Capitani, Nagaja
Benagiano, Marisa
Petrone, Luisa
Azzurri, Annalisa
Pratesi, Sara
D’Elios, Sofia
Cianchi, Fabio
Ortiz-Princz, Diana
Bizzaro, Nicola
D’Elios, Mario Milco
Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis
title Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis
title_full Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis
title_fullStr Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis
title_full_unstemmed Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis
title_short Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis
title_sort elevated il-19 serum levels in patients with pernicious anemia and autoimmune gastritis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036483/
https://www.ncbi.nlm.nih.gov/pubmed/35479078
http://dx.doi.org/10.3389/fimmu.2022.887256
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