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Synthesis of optically active 2-substituted azetidine-2-carbonitriles from chiral 1-arylethylamine via α-alkylation of N-borane complexes
The base-promoted α-alkylation of N-((S)-1-arylethyl)azetidine-2-carbonitriles 3via formation of their N-borane complexes 4 was investigated. For example, treatment of diastereomerically pure borane N-((S)-1′-(4′′-methoxyphenyl)ethyl)azetidine-2-carbonitrile complex (1S,2S,1′S)-4b with 1.2 equivalen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036535/ https://www.ncbi.nlm.nih.gov/pubmed/35479785 http://dx.doi.org/10.1039/d1ra04585g |