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Rational design of a potent macrocyclic peptide inhibitor targeting the PD-1/PD-L1 protein–protein interaction

We report optimization by rational design of JMPDP-027, a potent cyclic peptide that interferes with the PD-1/PD-L1 protein–protein interaction. JMPDP-027 shows a potent restoring ability towards T-cells with an EC(50) of 5.9 nM that is comparable to that of the anti-PD-1 monoclonal antibody pembrol...

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Detalles Bibliográficos
Autores principales:	Miao, Qi, Zhang, Wanheng, Zhang, Kuojun, Li, He, Zhu, Jidong, Jiang, Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036676/ https://www.ncbi.nlm.nih.gov/pubmed/35479790 http://dx.doi.org/10.1039/d1ra03118j

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