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A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population

OBJECTIVE: The nucleoside diphosphate linked moiety X (Nudix)-Type motif 15 (NUDT15) enzyme is involved in thiopurine metabolism. Genetic variants in the NUDT15 gene result in decreased NUDT15 activity, which in addition to decreased thiopurine S-methyltransferase (TPMT) activity, contributes to thi...

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Detalles Bibliográficos
Autores principales:	Poon, Kok-Siong, Imran, Izz Irfan B., Chew, Silvester Kheng-Han, Tan, Patrice, Tan, Karen Mei-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036696/ https://www.ncbi.nlm.nih.gov/pubmed/35468862 http://dx.doi.org/10.1186/s13104-021-05821-3

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