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Improving the reproducibility and integrity of research: what can different stakeholders contribute?
Increasing awareness of problems with the reproducibility and integrity of research led the UK Parliament Science and Technology Committee to launch, in July 2021, an inquiry into reproducibility and research integrity. We recognise at least four potential reasons why attempts to replicate a researc...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036698/ https://www.ncbi.nlm.nih.gov/pubmed/35468858 http://dx.doi.org/10.1186/s13104-022-06030-2 |
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author | Macleod, Malcolm |
author_facet | Macleod, Malcolm |
author_sort | Macleod, Malcolm |
collection | PubMed |
description | Increasing awareness of problems with the reproducibility and integrity of research led the UK Parliament Science and Technology Committee to launch, in July 2021, an inquiry into reproducibility and research integrity. We recognise at least four potential reasons why attempts to replicate a research finding may be unsuccessful: false positive statistical analyses, low generalisability of findings, suboptimal study designs (research integrity), and deliberate malfeasance (researcher integrity). It is important to make a distinction between the contributions of research integrity and of researcher integrity to the reproducibility crisis. While the impact of an individual instance of compromised researcher integrity is substantial, the aggregate impact of more prevalent problems with research integrity is likely much greater. The research community will be most efficient when failed replication efforts are never due to issues of research integrity or of researcher integrity, as this would allow focus on the scientific reasons for why two apparently similar experiments should reach different conclusions. We discuss the role of funders, institutions and government in addressing the “reproducibility crisis” before considering which interventions might have a positive impact on academia’s approach to reproducible research, and a possible role for a committee on research integrity. |
format | Online Article Text |
id | pubmed-9036698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90366982022-04-26 Improving the reproducibility and integrity of research: what can different stakeholders contribute? Macleod, Malcolm BMC Res Notes Commentary Increasing awareness of problems with the reproducibility and integrity of research led the UK Parliament Science and Technology Committee to launch, in July 2021, an inquiry into reproducibility and research integrity. We recognise at least four potential reasons why attempts to replicate a research finding may be unsuccessful: false positive statistical analyses, low generalisability of findings, suboptimal study designs (research integrity), and deliberate malfeasance (researcher integrity). It is important to make a distinction between the contributions of research integrity and of researcher integrity to the reproducibility crisis. While the impact of an individual instance of compromised researcher integrity is substantial, the aggregate impact of more prevalent problems with research integrity is likely much greater. The research community will be most efficient when failed replication efforts are never due to issues of research integrity or of researcher integrity, as this would allow focus on the scientific reasons for why two apparently similar experiments should reach different conclusions. We discuss the role of funders, institutions and government in addressing the “reproducibility crisis” before considering which interventions might have a positive impact on academia’s approach to reproducible research, and a possible role for a committee on research integrity. BioMed Central 2022-04-25 /pmc/articles/PMC9036698/ /pubmed/35468858 http://dx.doi.org/10.1186/s13104-022-06030-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Commentary Macleod, Malcolm Improving the reproducibility and integrity of research: what can different stakeholders contribute? |
title | Improving the reproducibility and integrity of research: what can different stakeholders contribute? |
title_full | Improving the reproducibility and integrity of research: what can different stakeholders contribute? |
title_fullStr | Improving the reproducibility and integrity of research: what can different stakeholders contribute? |
title_full_unstemmed | Improving the reproducibility and integrity of research: what can different stakeholders contribute? |
title_short | Improving the reproducibility and integrity of research: what can different stakeholders contribute? |
title_sort | improving the reproducibility and integrity of research: what can different stakeholders contribute? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036698/ https://www.ncbi.nlm.nih.gov/pubmed/35468858 http://dx.doi.org/10.1186/s13104-022-06030-2 |
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