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KSR2-14–3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma

BACKGROUND: Kinase suppressor of Ras 2 (KSR2) is a regulator of MAPK signaling that is overactivated in most hepatocellular carcinoma (HCC). We sought to determine the role of KSR2 in HCC pathogenesis. METHODS: We tested the level of KSR2 in HCC tissues and cell lines by tissue microarray, qPCR, and...

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Detalles Bibliográficos
Autores principales:	Gao, Chao, Wang, Si-wei, Lu, Jia-cheng, Chai, Xiao-qiang, Li, Yuan-cheng, Zhang, Peng-fei, Huang, Xiao-yong, Cai, Jia-bin, Zheng, Yi-min, Guo, Xiao-jun, Shi, Guo-ming, Ke, Ai-wu, Fan, Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036720/ https://www.ncbi.nlm.nih.gov/pubmed/35468812 http://dx.doi.org/10.1186/s40364-022-00361-9

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