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MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway

BACKGROUND: Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (Lin et al. in Cancer Cell 30:737–749, 2016). In paral...

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Detalles Bibliográficos
Autores principales:	Siemund, Anna Lena, Hanewald, Thomas, Kowarz, Eric, Marschalek, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036721/ https://www.ncbi.nlm.nih.gov/pubmed/35468859 http://dx.doi.org/10.1186/s13578-022-00781-y

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