HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status

BACKGROUND: Haplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are associated with radiological outcome, anti-TNF response and all cause-mortality in RA. RA is associated with cardiovascular (CV) morbidity and mortality,...

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Autores principales: Sharma, Seema, Plant, Darren, Bowes, John, Macgregor, Alex, Verstappen, Suzanne, Barton, Anne, Viatte, Sebastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036773/
https://www.ncbi.nlm.nih.gov/pubmed/35468805
http://dx.doi.org/10.1186/s13075-022-02775-0

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