Catalyst-free synthesis of novel 1,5-benzodiazepines and 3,4-dihydroquinoxalines using isocyanide-based one-pot, three- and four-component reactions

Reaction of benzimidazolone derivatives, or their thio- or aza-counterparts, with an isocyanide in the presence of acetone unexpectedly gave rise to novel tricyclic benzodiazepine derivatives in good yield by means of a four-component reaction incorporating two moles of acetone. Benzimidazole starti...

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Detalles Bibliográficos
Autores principales: Mohlala, Reagan L., Coyanis, E. Mabel, Fernandes, Manuel A., Bode, Moira L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036818/
https://www.ncbi.nlm.nih.gov/pubmed/35479051
http://dx.doi.org/10.1039/d1ra04444c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036818/
https://www.ncbi.nlm.nih.gov/pubmed/35479051
http://dx.doi.org/10.1039/d1ra04444c

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