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Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study
BACKGROUND: Rheumatoid arthritis (RA) is an inflammatory disease that is characterized by the overproduction of cytokines. Among the newly discovered cytokines are the adipokines which are primarily produced by and released from the adipose tissue and some immune cells, as well as synovial cells. th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036819/ https://www.ncbi.nlm.nih.gov/pubmed/35462548 http://dx.doi.org/10.1186/s41927-022-00254-2 |
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author | Taherian, Marjan Almasi, Simin Mehdizadeh, Saber Fazeli, Banafshe Kalantari, Mahsa Bayati, Paria Pashangzadeh, Salar Mojtabavi, Nazanin |
author_facet | Taherian, Marjan Almasi, Simin Mehdizadeh, Saber Fazeli, Banafshe Kalantari, Mahsa Bayati, Paria Pashangzadeh, Salar Mojtabavi, Nazanin |
author_sort | Taherian, Marjan |
collection | PubMed |
description | BACKGROUND: Rheumatoid arthritis (RA) is an inflammatory disease that is characterized by the overproduction of cytokines. Among the newly discovered cytokines are the adipokines which are primarily produced by and released from the adipose tissue and some immune cells, as well as synovial cells. they are involved in various immune responses and inflammatory processes. However, there are controversial data regarding the pro-inflammatory or anti-inflammatory effects of adipokines in different conditions. C1q/TNF-related protein 5 (CTRP5) is a newly identified adipokine and adiponectin paralogous protein, which has been shown to be correlated with inflammatory diseases. Accordingly, the present study was designed to investigate the serum levels of CTRP5 in RA patients and evaluate any possible alterations in comparison to healthy individuals. METHODS: Serum CTRP-5 levels were measured in 46 patients and 22 healthy controls by ELISA. The demographic, laboratory, and clinical features of the patients were also evaluated in order to find any correlations. RESULTS: Serum levels of CTRP-5 were significantly (p < 0.0001) higher in patients with RA (14.88 ± 25.55) compared to healthy controls (4.262 ± 2.374). There was a significant correlation between serum CTRP-5 levels and triglyceride (TG) (r: − 0.3010, p: 0.0498), as well as erythrocyte sedimentation rate (ESR) (r: 0.3139, p: 0.0457), C-reactive protein (CRP) (r: 0.5140, p: 0.0008), and the number of white blood cells (WBC) (r: 0.3380, p: 0.0307), which are considered as the markers indicating the extent of inflammation. Moreover, CTRP-5 was found to be correlated with interstitial lung disease (ILD) (r: 0.3416, p: 0.0385), a comorbidity associated with RA disease. CONCLUSION: This study demonstrated the increased level of circulating CTRP-5 in RA patients, which correlated with some inflammation-associated parameters and RA-associated comorbidities. Our observations suggest CTRP-5 as a putative inflammatory biomarker in RA, which may be useful besides the other disease-related markers. |
format | Online Article Text |
id | pubmed-9036819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90368192022-04-26 Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study Taherian, Marjan Almasi, Simin Mehdizadeh, Saber Fazeli, Banafshe Kalantari, Mahsa Bayati, Paria Pashangzadeh, Salar Mojtabavi, Nazanin BMC Rheumatol Research Article BACKGROUND: Rheumatoid arthritis (RA) is an inflammatory disease that is characterized by the overproduction of cytokines. Among the newly discovered cytokines are the adipokines which are primarily produced by and released from the adipose tissue and some immune cells, as well as synovial cells. they are involved in various immune responses and inflammatory processes. However, there are controversial data regarding the pro-inflammatory or anti-inflammatory effects of adipokines in different conditions. C1q/TNF-related protein 5 (CTRP5) is a newly identified adipokine and adiponectin paralogous protein, which has been shown to be correlated with inflammatory diseases. Accordingly, the present study was designed to investigate the serum levels of CTRP5 in RA patients and evaluate any possible alterations in comparison to healthy individuals. METHODS: Serum CTRP-5 levels were measured in 46 patients and 22 healthy controls by ELISA. The demographic, laboratory, and clinical features of the patients were also evaluated in order to find any correlations. RESULTS: Serum levels of CTRP-5 were significantly (p < 0.0001) higher in patients with RA (14.88 ± 25.55) compared to healthy controls (4.262 ± 2.374). There was a significant correlation between serum CTRP-5 levels and triglyceride (TG) (r: − 0.3010, p: 0.0498), as well as erythrocyte sedimentation rate (ESR) (r: 0.3139, p: 0.0457), C-reactive protein (CRP) (r: 0.5140, p: 0.0008), and the number of white blood cells (WBC) (r: 0.3380, p: 0.0307), which are considered as the markers indicating the extent of inflammation. Moreover, CTRP-5 was found to be correlated with interstitial lung disease (ILD) (r: 0.3416, p: 0.0385), a comorbidity associated with RA disease. CONCLUSION: This study demonstrated the increased level of circulating CTRP-5 in RA patients, which correlated with some inflammation-associated parameters and RA-associated comorbidities. Our observations suggest CTRP-5 as a putative inflammatory biomarker in RA, which may be useful besides the other disease-related markers. BioMed Central 2022-04-25 /pmc/articles/PMC9036819/ /pubmed/35462548 http://dx.doi.org/10.1186/s41927-022-00254-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Taherian, Marjan Almasi, Simin Mehdizadeh, Saber Fazeli, Banafshe Kalantari, Mahsa Bayati, Paria Pashangzadeh, Salar Mojtabavi, Nazanin Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study |
title | Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study |
title_full | Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study |
title_fullStr | Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study |
title_full_unstemmed | Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study |
title_short | Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study |
title_sort | circulating ctrp5 in rheumatoid arthritis: an exploratory biomarker study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036819/ https://www.ncbi.nlm.nih.gov/pubmed/35462548 http://dx.doi.org/10.1186/s41927-022-00254-2 |
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