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Markovnikov-addition of H-phosphonates to terminal alkynes under metal- and solvent-free conditions

An addition of H-phosphonates to aryl alkynes was realized under solvent- and metal-free conditions, affording Markovnikov-selective α-vinylphosphonates in moderate to good yields. A wide range of aryl alkynes could be applied for the reaction. A tentative mechanism of addition–substitution was prop...

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Detalles Bibliográficos
Autores principales: Xin, Nana, Lian, Yongjian, Lv, Yongzheng, Wang, Yongjie, Huang, Xian-Qiang, Zhao, Chang-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036860/
https://www.ncbi.nlm.nih.gov/pubmed/35481042
http://dx.doi.org/10.1039/d1ra04306d
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author Xin, Nana
Lian, Yongjian
Lv, Yongzheng
Wang, Yongjie
Huang, Xian-Qiang
Zhao, Chang-Qiu
author_facet Xin, Nana
Lian, Yongjian
Lv, Yongzheng
Wang, Yongjie
Huang, Xian-Qiang
Zhao, Chang-Qiu
author_sort Xin, Nana
collection PubMed
description An addition of H-phosphonates to aryl alkynes was realized under solvent- and metal-free conditions, affording Markovnikov-selective α-vinylphosphonates in moderate to good yields. A wide range of aryl alkynes could be applied for the reaction. A tentative mechanism of addition–substitution was proposed based on in situ(31)P {(1)H} NMR studies.
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spelling pubmed-90368602022-04-26 Markovnikov-addition of H-phosphonates to terminal alkynes under metal- and solvent-free conditions Xin, Nana Lian, Yongjian Lv, Yongzheng Wang, Yongjie Huang, Xian-Qiang Zhao, Chang-Qiu RSC Adv Chemistry An addition of H-phosphonates to aryl alkynes was realized under solvent- and metal-free conditions, affording Markovnikov-selective α-vinylphosphonates in moderate to good yields. A wide range of aryl alkynes could be applied for the reaction. A tentative mechanism of addition–substitution was proposed based on in situ(31)P {(1)H} NMR studies. The Royal Society of Chemistry 2021-07-19 /pmc/articles/PMC9036860/ /pubmed/35481042 http://dx.doi.org/10.1039/d1ra04306d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Xin, Nana
Lian, Yongjian
Lv, Yongzheng
Wang, Yongjie
Huang, Xian-Qiang
Zhao, Chang-Qiu
Markovnikov-addition of H-phosphonates to terminal alkynes under metal- and solvent-free conditions
title Markovnikov-addition of H-phosphonates to terminal alkynes under metal- and solvent-free conditions
title_full Markovnikov-addition of H-phosphonates to terminal alkynes under metal- and solvent-free conditions
title_fullStr Markovnikov-addition of H-phosphonates to terminal alkynes under metal- and solvent-free conditions
title_full_unstemmed Markovnikov-addition of H-phosphonates to terminal alkynes under metal- and solvent-free conditions
title_short Markovnikov-addition of H-phosphonates to terminal alkynes under metal- and solvent-free conditions
title_sort markovnikov-addition of h-phosphonates to terminal alkynes under metal- and solvent-free conditions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036860/
https://www.ncbi.nlm.nih.gov/pubmed/35481042
http://dx.doi.org/10.1039/d1ra04306d
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