Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives

A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag(2)CO(3) as the oxidant and Pd(OAc)(2) as the catalyst precursor. The data obtained in this study support a reaction mechanism...

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Detalles Bibliográficos
Autores principales: Bellina, Fabio, Biagetti, Matteo, Guariento, Sara, Lessi, Marco, Fausti, Mattia, Ronchi, Paolo, Rosadoni, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036978/
https://www.ncbi.nlm.nih.gov/pubmed/35478867
http://dx.doi.org/10.1039/d1ra05303e
Descripción
Sumario:A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag(2)CO(3) as the oxidant and Pd(OAc)(2) as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway.

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