Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives

A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag(2)CO(3) as the oxidant and Pd(OAc)(2) as the catalyst precursor. The data obtained in this study support a reaction mechanism...

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Detalles Bibliográficos
Autores principales: Bellina, Fabio, Biagetti, Matteo, Guariento, Sara, Lessi, Marco, Fausti, Mattia, Ronchi, Paolo, Rosadoni, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036978/
https://www.ncbi.nlm.nih.gov/pubmed/35478867
http://dx.doi.org/10.1039/d1ra05303e
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author Bellina, Fabio
Biagetti, Matteo
Guariento, Sara
Lessi, Marco
Fausti, Mattia
Ronchi, Paolo
Rosadoni, Elisabetta
author_facet Bellina, Fabio
Biagetti, Matteo
Guariento, Sara
Lessi, Marco
Fausti, Mattia
Ronchi, Paolo
Rosadoni, Elisabetta
author_sort Bellina, Fabio
collection PubMed
description A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag(2)CO(3) as the oxidant and Pd(OAc)(2) as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway.
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spelling pubmed-90369782022-04-26 Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives Bellina, Fabio Biagetti, Matteo Guariento, Sara Lessi, Marco Fausti, Mattia Ronchi, Paolo Rosadoni, Elisabetta RSC Adv Chemistry A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag(2)CO(3) as the oxidant and Pd(OAc)(2) as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway. The Royal Society of Chemistry 2021-07-22 /pmc/articles/PMC9036978/ /pubmed/35478867 http://dx.doi.org/10.1039/d1ra05303e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Bellina, Fabio
Biagetti, Matteo
Guariento, Sara
Lessi, Marco
Fausti, Mattia
Ronchi, Paolo
Rosadoni, Elisabetta
Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives
title Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives
title_full Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives
title_fullStr Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives
title_full_unstemmed Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives
title_short Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives
title_sort ligand-free pd/ag-mediated dehydrogenative alkynylation of imidazole derivatives
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036978/
https://www.ncbi.nlm.nih.gov/pubmed/35478867
http://dx.doi.org/10.1039/d1ra05303e
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