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Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium

Regardless of the sustainable development path, today, there are highly demanded chemical productions still operating that bear environmental and technological risks inherited from the previous century. The fabrication of nitro compounds, and nitroarenes in particular, is traditionally associated wi...

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Autores principales: Kharchenko, Alexandr K., Fauziev, Ruslan V., Zharkov, Mikhail N., Kuchurov, Ilya V., Zlotin, Sergei G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037121/
https://www.ncbi.nlm.nih.gov/pubmed/35479456
http://dx.doi.org/10.1039/d1ra04536a
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author Kharchenko, Alexandr K.
Fauziev, Ruslan V.
Zharkov, Mikhail N.
Kuchurov, Ilya V.
Zlotin, Sergei G.
author_facet Kharchenko, Alexandr K.
Fauziev, Ruslan V.
Zharkov, Mikhail N.
Kuchurov, Ilya V.
Zlotin, Sergei G.
author_sort Kharchenko, Alexandr K.
collection PubMed
description Regardless of the sustainable development path, today, there are highly demanded chemical productions still operating that bear environmental and technological risks inherited from the previous century. The fabrication of nitro compounds, and nitroarenes in particular, is traditionally associated with acidic wastes formed in nitration reactions exploiting mixed acids. However, nitroarenes are indispensable for industrial and military applications. We faced the challenge and developed a greener, safer, and yet effective method for the production of nitroaromatics. The proposed approach comprises the application of an eco-friendly nitrating agent, namely dinitrogen pentoxide (DNP), in the medium of liquefied 1,1,1,2-tetrafluoroethane (TFE) – one of the most non-hazardous Freons. Importantly, the used TFE is not emitted into the atmosphere but is effortlessly recondensed and returned into the process. DNP is obtained via the oxidation of dinitrogen tetroxide with ozone. The elaborated method is characterized by high yields of the targeted nitro arenes, mild reaction conditions, and minimal amount of easy-to-utilize wastes.
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spelling pubmed-90371212022-04-26 Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium Kharchenko, Alexandr K. Fauziev, Ruslan V. Zharkov, Mikhail N. Kuchurov, Ilya V. Zlotin, Sergei G. RSC Adv Chemistry Regardless of the sustainable development path, today, there are highly demanded chemical productions still operating that bear environmental and technological risks inherited from the previous century. The fabrication of nitro compounds, and nitroarenes in particular, is traditionally associated with acidic wastes formed in nitration reactions exploiting mixed acids. However, nitroarenes are indispensable for industrial and military applications. We faced the challenge and developed a greener, safer, and yet effective method for the production of nitroaromatics. The proposed approach comprises the application of an eco-friendly nitrating agent, namely dinitrogen pentoxide (DNP), in the medium of liquefied 1,1,1,2-tetrafluoroethane (TFE) – one of the most non-hazardous Freons. Importantly, the used TFE is not emitted into the atmosphere but is effortlessly recondensed and returned into the process. DNP is obtained via the oxidation of dinitrogen tetroxide with ozone. The elaborated method is characterized by high yields of the targeted nitro arenes, mild reaction conditions, and minimal amount of easy-to-utilize wastes. The Royal Society of Chemistry 2021-07-27 /pmc/articles/PMC9037121/ /pubmed/35479456 http://dx.doi.org/10.1039/d1ra04536a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kharchenko, Alexandr K.
Fauziev, Ruslan V.
Zharkov, Mikhail N.
Kuchurov, Ilya V.
Zlotin, Sergei G.
Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium
title Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium
title_full Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium
title_fullStr Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium
title_full_unstemmed Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium
title_short Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium
title_sort nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037121/
https://www.ncbi.nlm.nih.gov/pubmed/35479456
http://dx.doi.org/10.1039/d1ra04536a
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