Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects

(1)H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after secon...

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Autores principales: Ghini, Veronica, Maggi, Laura, Mazzoni, Alessio, Spinicci, Michele, Zammarchi, Lorenzo, Bartoloni, Alessandro, Annunziato, Francesco, Turano, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037139/
https://www.ncbi.nlm.nih.gov/pubmed/35480886
http://dx.doi.org/10.3389/fmolb.2022.839809
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author Ghini, Veronica
Maggi, Laura
Mazzoni, Alessio
Spinicci, Michele
Zammarchi, Lorenzo
Bartoloni, Alessandro
Annunziato, Francesco
Turano, Paola
author_facet Ghini, Veronica
Maggi, Laura
Mazzoni, Alessio
Spinicci, Michele
Zammarchi, Lorenzo
Bartoloni, Alessandro
Annunziato, Francesco
Turano, Paola
author_sort Ghini, Veronica
collection PubMed
description (1)H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.
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spelling pubmed-90371392022-04-26 Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects Ghini, Veronica Maggi, Laura Mazzoni, Alessio Spinicci, Michele Zammarchi, Lorenzo Bartoloni, Alessandro Annunziato, Francesco Turano, Paola Front Mol Biosci Molecular Biosciences (1)H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition. Frontiers Media S.A. 2022-04-05 /pmc/articles/PMC9037139/ /pubmed/35480886 http://dx.doi.org/10.3389/fmolb.2022.839809 Text en Copyright © 2022 Ghini, Maggi, Mazzoni, Spinicci, Zammarchi, Bartoloni, Annunziato and Turano. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Ghini, Veronica
Maggi, Laura
Mazzoni, Alessio
Spinicci, Michele
Zammarchi, Lorenzo
Bartoloni, Alessandro
Annunziato, Francesco
Turano, Paola
Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects
title Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects
title_full Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects
title_fullStr Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects
title_full_unstemmed Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects
title_short Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects
title_sort serum nmr profiling reveals differential alterations in the lipoproteome induced by pfizer-biontech vaccine in covid-19 recovered subjects and naïve subjects
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037139/
https://www.ncbi.nlm.nih.gov/pubmed/35480886
http://dx.doi.org/10.3389/fmolb.2022.839809
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