Editing cholesterol out of the blood

In patients with high cholesterol and at risk of cardiovascular disease, inhibitors of PCSK9 are useful in lowering lipid levels but must be dosed regularly. A recent study in Nature by Munsunuru and colleagues explores the possibility of permanently disrupting PCSK9 expression via in vivo CRISPR ge...

Descripción completa

Detalles Bibliográficos
Autor principal: Abbott, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037316/
https://www.ncbi.nlm.nih.gov/pubmed/35602209
http://dx.doi.org/10.1038/s43856-021-00011-5
_version_ 1784693709339623424
author Abbott, Ben
author_facet Abbott, Ben
author_sort Abbott, Ben
collection PubMed
description In patients with high cholesterol and at risk of cardiovascular disease, inhibitors of PCSK9 are useful in lowering lipid levels but must be dosed regularly. A recent study in Nature by Munsunuru and colleagues explores the possibility of permanently disrupting PCSK9 expression via in vivo CRISPR gene editing in non-human primates, with long-lasting reductions in LDL cholesterol.
format Online
Article
Text
id pubmed-9037316
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-90373162022-05-20 Editing cholesterol out of the blood Abbott, Ben Commun Med (Lond) Research Highlight In patients with high cholesterol and at risk of cardiovascular disease, inhibitors of PCSK9 are useful in lowering lipid levels but must be dosed regularly. A recent study in Nature by Munsunuru and colleagues explores the possibility of permanently disrupting PCSK9 expression via in vivo CRISPR gene editing in non-human primates, with long-lasting reductions in LDL cholesterol. Nature Publishing Group UK 2021-06-30 /pmc/articles/PMC9037316/ /pubmed/35602209 http://dx.doi.org/10.1038/s43856-021-00011-5 Text en © Springer Nature Limited 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Highlight
Abbott, Ben
Editing cholesterol out of the blood
title Editing cholesterol out of the blood
title_full Editing cholesterol out of the blood
title_fullStr Editing cholesterol out of the blood
title_full_unstemmed Editing cholesterol out of the blood
title_short Editing cholesterol out of the blood
title_sort editing cholesterol out of the blood
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037316/
https://www.ncbi.nlm.nih.gov/pubmed/35602209
http://dx.doi.org/10.1038/s43856-021-00011-5
work_keys_str_mv AT abbottben editingcholesteroloutoftheblood

Ejemplares similares