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Design, synthesis and mechanistic study of new benzenesulfonamide derivatives as anticancer and antimicrobial agents via carbonic anhydrase IX inhibition

Changes in gene expression cause uncontrolled cell proliferation and consequently tumor hypoxia. The tumor cells shift their metabolism to anaerobic glycolysis with a significant modification in pH. Therefore, an over expression of carbonic anhydrase IX (CA IX) genes was detected in many solid tumor...

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Detalles Bibliográficos
Autores principales:	Nemr, Mohamed T. M., AboulMagd, Asmaa M., Hassan, Hossam M., Hamed, Ahmed A., Hamed, Mohamed I. A., Elsaadi, Mohamed T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037358/ https://www.ncbi.nlm.nih.gov/pubmed/35479426 http://dx.doi.org/10.1039/d1ra05277b

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