Deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions

We highlight a convenient synthesis to selectively deuterate an aryl C–H hydrogen bond donor in an arylethynyl bisurea supramolecular anion receptor and use the Perrin method of competitive titrations to study the deuterium equilibrium isotope effects (DEIE) of anion binding for HS(−), Cl(−), and Br...

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Autores principales: Fargher, Hazel A., Nickels, Russell A., de Faria, Thaís P., Haley, Michael M., Pluth, Michael D., Johnson, Darren W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037421/
https://www.ncbi.nlm.nih.gov/pubmed/35479978
http://dx.doi.org/10.1039/d1ra05711a
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author Fargher, Hazel A.
Nickels, Russell A.
de Faria, Thaís P.
Haley, Michael M.
Pluth, Michael D.
Johnson, Darren W.
author_facet Fargher, Hazel A.
Nickels, Russell A.
de Faria, Thaís P.
Haley, Michael M.
Pluth, Michael D.
Johnson, Darren W.
author_sort Fargher, Hazel A.
collection PubMed
description We highlight a convenient synthesis to selectively deuterate an aryl C–H hydrogen bond donor in an arylethynyl bisurea supramolecular anion receptor and use the Perrin method of competitive titrations to study the deuterium equilibrium isotope effects (DEIE) of anion binding for HS(−), Cl(−), and Br(−). This work highlights the utility and also challenges in using this method to determine EIE with highly reactive and/or weakly binding anions.
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spelling pubmed-90374212022-04-26 Deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions Fargher, Hazel A. Nickels, Russell A. de Faria, Thaís P. Haley, Michael M. Pluth, Michael D. Johnson, Darren W. RSC Adv Chemistry We highlight a convenient synthesis to selectively deuterate an aryl C–H hydrogen bond donor in an arylethynyl bisurea supramolecular anion receptor and use the Perrin method of competitive titrations to study the deuterium equilibrium isotope effects (DEIE) of anion binding for HS(−), Cl(−), and Br(−). This work highlights the utility and also challenges in using this method to determine EIE with highly reactive and/or weakly binding anions. The Royal Society of Chemistry 2021-08-04 /pmc/articles/PMC9037421/ /pubmed/35479978 http://dx.doi.org/10.1039/d1ra05711a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Fargher, Hazel A.
Nickels, Russell A.
de Faria, Thaís P.
Haley, Michael M.
Pluth, Michael D.
Johnson, Darren W.
Deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions
title Deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions
title_full Deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions
title_fullStr Deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions
title_full_unstemmed Deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions
title_short Deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions
title_sort deuterium equilibrium isotope effects in a supramolecular receptor for the hydrochalcogenide and halide anions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037421/
https://www.ncbi.nlm.nih.gov/pubmed/35479978
http://dx.doi.org/10.1039/d1ra05711a
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