Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

The Mycobacterium ulcerans exotoxin, mycolactone, is responsible for the immunosuppression and tissue necrosis that characterizes Buruli ulcer. Mycolactone inhibits SEC61-dependent co-translational translocation of proteins into the endoplasmic reticulum and the resultant cytosolic translation trigg...

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Detalles Bibliográficos
Autores principales: Hall, Belinda S, Dos Santos, Scott J, Hsieh, Louise Tzung-Harn, Manifava, Maria, Ruf, Marie-Thérèse, Pluschke, Gerd, Ktistakis, Nicholas, Simmonds, Rachel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037441/
https://www.ncbi.nlm.nih.gov/pubmed/34424124
http://dx.doi.org/10.1080/15548627.2021.1961067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037441/
https://www.ncbi.nlm.nih.gov/pubmed/34424124
http://dx.doi.org/10.1080/15548627.2021.1961067

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