Mechanisms of non-coding RNA-modulated alternative splicing in cancer

Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiat...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiaolin, Hua, Jinghan, Li, Jingxin, Zhang, Jiahui, Dzakah, Emmanuel Enoch, Cao, Guozhen, Lin, Wenchu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037454/
https://www.ncbi.nlm.nih.gov/pubmed/35427215
http://dx.doi.org/10.1080/15476286.2022.2062846
Descripción
Sumario:Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis.

Ejemplares similares