Mechanisms of non-coding RNA-modulated alternative splicing in cancer

Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiat...

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Detalles Bibliográficos
Autores principales: Wang, Xiaolin, Hua, Jinghan, Li, Jingxin, Zhang, Jiahui, Dzakah, Emmanuel Enoch, Cao, Guozhen, Lin, Wenchu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037454/
https://www.ncbi.nlm.nih.gov/pubmed/35427215
http://dx.doi.org/10.1080/15476286.2022.2062846
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author Wang, Xiaolin
Hua, Jinghan
Li, Jingxin
Zhang, Jiahui
Dzakah, Emmanuel Enoch
Cao, Guozhen
Lin, Wenchu
author_facet Wang, Xiaolin
Hua, Jinghan
Li, Jingxin
Zhang, Jiahui
Dzakah, Emmanuel Enoch
Cao, Guozhen
Lin, Wenchu
author_sort Wang, Xiaolin
collection PubMed
description Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis.
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spelling pubmed-90374542022-04-26 Mechanisms of non-coding RNA-modulated alternative splicing in cancer Wang, Xiaolin Hua, Jinghan Li, Jingxin Zhang, Jiahui Dzakah, Emmanuel Enoch Cao, Guozhen Lin, Wenchu RNA Biol Review Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis. Taylor & Francis 2022-04-15 /pmc/articles/PMC9037454/ /pubmed/35427215 http://dx.doi.org/10.1080/15476286.2022.2062846 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wang, Xiaolin
Hua, Jinghan
Li, Jingxin
Zhang, Jiahui
Dzakah, Emmanuel Enoch
Cao, Guozhen
Lin, Wenchu
Mechanisms of non-coding RNA-modulated alternative splicing in cancer
title Mechanisms of non-coding RNA-modulated alternative splicing in cancer
title_full Mechanisms of non-coding RNA-modulated alternative splicing in cancer
title_fullStr Mechanisms of non-coding RNA-modulated alternative splicing in cancer
title_full_unstemmed Mechanisms of non-coding RNA-modulated alternative splicing in cancer
title_short Mechanisms of non-coding RNA-modulated alternative splicing in cancer
title_sort mechanisms of non-coding rna-modulated alternative splicing in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037454/
https://www.ncbi.nlm.nih.gov/pubmed/35427215
http://dx.doi.org/10.1080/15476286.2022.2062846
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