A Dictyostelium model for BPAN disease reveals a functional relationship between the WDR45/WIPI4 homolog Wdr45l and Vmp1 in the regulation of autophagy-associated PtdIns3P and ER stress

PROPPINs are conserved PtdIns3P-binding proteins required for autophagosome biogenesis that fold into a characteristic group of seven-bladed beta-propellers. Mutations in WDR45/WIPI4, a human member of this family, lead to BPAN, a rare form of neurodegeneration. We have generated mutants for the two...

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Detalles Bibliográficos
Autores principales: Tornero-Écija, Alba, Tábara, Luis-Carlos, Bueno-Arribas, Miranda, Antón-Esteban, Laura, Navarro-Gómez, Cristina, Sánchez, Irene, Vincent, Olivier, Escalante, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037511/
https://www.ncbi.nlm.nih.gov/pubmed/34328055
http://dx.doi.org/10.1080/15548627.2021.1953262

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