Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

Epithelial-mesenchymal transition (EMT) programs operate within carcinoma cells in which they generate phenotypes associated with malignant progression. In their various manifestations, EMT programs enable epithelial cells to enter into a series of intermediate states arrayed along the E-M phenotypi...

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Detalles Bibliográficos
Autores principales: Zhang, Yun, Donaher, Joana Liu, Das, Sunny, Li, Xin, Reinhardt, Ferenc, Krall, Jordan A., Lambert, Arthur W., Thiru, Prathapan, Keys, Heather R., Khan, Mehreen, Hofree, Matan, Wilson, Molly M., Yedier-Bayram, Ozlem, Lack, Nathan A., Onder, Tamer T., Bagci-Onder, Tugba, Tyler, Michael, Tirosh, Itay, Regev, Aviv, Lees, Jacqueline A., Weinberg, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037576/
https://www.ncbi.nlm.nih.gov/pubmed/35411083
http://dx.doi.org/10.1038/s41556-022-00877-0

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