Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions

A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks is described. The rigid biaryl phosphacycles are efficient for Suzuki–Miyaura cross-coupling of aryl bromides and chlorides. In particular, coupling reactions of the challenging sterically hindered...

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Autores principales: Lamola, Jairus L., Moshapo, Paseka T., Holzapfel, Cedric W., Maumela, Munaka Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037619/
https://www.ncbi.nlm.nih.gov/pubmed/35480011
http://dx.doi.org/10.1039/d1ra04947j
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author Lamola, Jairus L.
Moshapo, Paseka T.
Holzapfel, Cedric W.
Maumela, Munaka Christopher
author_facet Lamola, Jairus L.
Moshapo, Paseka T.
Holzapfel, Cedric W.
Maumela, Munaka Christopher
author_sort Lamola, Jairus L.
collection PubMed
description A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks is described. The rigid biaryl phosphacycles are efficient for Suzuki–Miyaura cross-coupling of aryl bromides and chlorides. In particular, coupling reactions of the challenging sterically hindered and heterocyclic substrates were viable at room temperature.
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spelling pubmed-90376192022-04-26 Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions Lamola, Jairus L. Moshapo, Paseka T. Holzapfel, Cedric W. Maumela, Munaka Christopher RSC Adv Chemistry A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks is described. The rigid biaryl phosphacycles are efficient for Suzuki–Miyaura cross-coupling of aryl bromides and chlorides. In particular, coupling reactions of the challenging sterically hindered and heterocyclic substrates were viable at room temperature. The Royal Society of Chemistry 2021-08-05 /pmc/articles/PMC9037619/ /pubmed/35480011 http://dx.doi.org/10.1039/d1ra04947j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Lamola, Jairus L.
Moshapo, Paseka T.
Holzapfel, Cedric W.
Maumela, Munaka Christopher
Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions
title Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions
title_full Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions
title_fullStr Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions
title_full_unstemmed Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions
title_short Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki–Miyaura cross-coupling reactions
title_sort evaluation of p-bridged biaryl phosphine ligands in palladium-catalysed suzuki–miyaura cross-coupling reactions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037619/
https://www.ncbi.nlm.nih.gov/pubmed/35480011
http://dx.doi.org/10.1039/d1ra04947j
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