SWIR emissive RosIndolizine dyes with nanoencapsulation in water soluble dendrimers

Shortwave infrared (SWIR) emission has great potential for deep-tissue in vivo biological imaging with high resolution. In this article, the synthesis and characterization of two new xanthene-based RosIndolizine dyes coded (Ph)RosIndz and (tol)RosIndz is presented. The dyes are characterized via fem...

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Detalles Bibliográficos
Autores principales: Chatterjee, Satadru, Meador, William E., Smith, Cameron, Chandrasiri, Indika, Zia, Mohammad Farid, Nguyen, Jay, Dorris, Austin, Flynt, Alex, Watkins, Davita L., Hammer, Nathan I., Delcamp, Jared H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037842/
https://www.ncbi.nlm.nih.gov/pubmed/35480767
http://dx.doi.org/10.1039/d1ra05479a
Descripción
Sumario:Shortwave infrared (SWIR) emission has great potential for deep-tissue in vivo biological imaging with high resolution. In this article, the synthesis and characterization of two new xanthene-based RosIndolizine dyes coded (Ph)RosIndz and (tol)RosIndz is presented. The dyes are characterized via femtosecond transient absorption spectroscopy as well as steady-state absorption and emission spectroscopies. The emission of these dyes is shown in the SWIR region with peak emission at 1097 nm. (Tol)RosIndz was encapsulated with an amphiphilic linear dendritic block co-polymer (LDBC) coded 10-PhPCL-G3 with high uptake yield. Further, cellular toxicity was examined in vitro using HEK (human embryonic kidney) cells where a >90% cell viability was observed at practical concentrations of the encapsulated dye which indicates low toxicity and reasonable biocompatibility.

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