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Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes

Many adult tissues are composed of differentiated cells and stem cells, each working in a coordinated manner to maintain tissue homeostasis during physiological cell turnover. Old differentiated cells are believed to typically die by apoptosis. Here, we discovered a previously uncharacterized, new p...

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Autores principales: Ciesielski, Hanna M., Nishida, Hiroshi, Takano, Tomomi, Fukuhara, Aya, Otani, Tetsuhisa, Ikegawa, Yuko, Okada, Morihiro, Nishimura, Takashi, Furuse, Mikio, Yoo, Sa Kan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037934/
https://www.ncbi.nlm.nih.gov/pubmed/35468130
http://dx.doi.org/10.1371/journal.pbio.3001586
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author Ciesielski, Hanna M.
Nishida, Hiroshi
Takano, Tomomi
Fukuhara, Aya
Otani, Tetsuhisa
Ikegawa, Yuko
Okada, Morihiro
Nishimura, Takashi
Furuse, Mikio
Yoo, Sa Kan
author_facet Ciesielski, Hanna M.
Nishida, Hiroshi
Takano, Tomomi
Fukuhara, Aya
Otani, Tetsuhisa
Ikegawa, Yuko
Okada, Morihiro
Nishimura, Takashi
Furuse, Mikio
Yoo, Sa Kan
author_sort Ciesielski, Hanna M.
collection PubMed
description Many adult tissues are composed of differentiated cells and stem cells, each working in a coordinated manner to maintain tissue homeostasis during physiological cell turnover. Old differentiated cells are believed to typically die by apoptosis. Here, we discovered a previously uncharacterized, new phenomenon, which we name erebosis based on the ancient Greek word erebos (“complete darkness”), in the gut enterocytes of adult Drosophila. Cells that undergo erebosis lose cytoskeleton, cell adhesion, organelles and fluorescent proteins, but accumulate Angiotensin-converting enzyme (Ance). Their nuclei become flat and occasionally difficult to detect. Erebotic cells do not have characteristic features of apoptosis, necrosis, or autophagic cell death. Inhibition of apoptosis prevents neither the gut cell turnover nor erebosis. We hypothesize that erebosis is a cell death mechanism for the enterocyte flux to mediate tissue homeostasis in the gut.
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spelling pubmed-90379342022-04-26 Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes Ciesielski, Hanna M. Nishida, Hiroshi Takano, Tomomi Fukuhara, Aya Otani, Tetsuhisa Ikegawa, Yuko Okada, Morihiro Nishimura, Takashi Furuse, Mikio Yoo, Sa Kan PLoS Biol Discovery Report Many adult tissues are composed of differentiated cells and stem cells, each working in a coordinated manner to maintain tissue homeostasis during physiological cell turnover. Old differentiated cells are believed to typically die by apoptosis. Here, we discovered a previously uncharacterized, new phenomenon, which we name erebosis based on the ancient Greek word erebos (“complete darkness”), in the gut enterocytes of adult Drosophila. Cells that undergo erebosis lose cytoskeleton, cell adhesion, organelles and fluorescent proteins, but accumulate Angiotensin-converting enzyme (Ance). Their nuclei become flat and occasionally difficult to detect. Erebotic cells do not have characteristic features of apoptosis, necrosis, or autophagic cell death. Inhibition of apoptosis prevents neither the gut cell turnover nor erebosis. We hypothesize that erebosis is a cell death mechanism for the enterocyte flux to mediate tissue homeostasis in the gut. Public Library of Science 2022-04-25 /pmc/articles/PMC9037934/ /pubmed/35468130 http://dx.doi.org/10.1371/journal.pbio.3001586 Text en © 2022 Ciesielski et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Discovery Report
Ciesielski, Hanna M.
Nishida, Hiroshi
Takano, Tomomi
Fukuhara, Aya
Otani, Tetsuhisa
Ikegawa, Yuko
Okada, Morihiro
Nishimura, Takashi
Furuse, Mikio
Yoo, Sa Kan
Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
title Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
title_full Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
title_fullStr Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
title_full_unstemmed Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
title_short Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
title_sort erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
topic Discovery Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037934/
https://www.ncbi.nlm.nih.gov/pubmed/35468130
http://dx.doi.org/10.1371/journal.pbio.3001586
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